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    CG7506 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7506provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035805
    Locus tag
    Dmel_CG7506
    See related
    AllianceGenome:FB:FBgn0035805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7506; dTMEM70
    Summary
    Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Is active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 2. Orthologous to human TMEM70 (transmembrane protein 70). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7506 in Genome Data Viewer
    Location:
    66A8-66A8; 3-21 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7640798..7641648, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7633898..7634748, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ubiquitin-related modifier 1 Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SD Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ankyrin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis. Murari A, et al. iScience, 2021 Aug 20. PMID 34386730, Free PMC Article
    2. Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes. Yu J, et al. Development, 2016 Aug 15. PMID 27471256
    3. Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila. Ding K, et al. G3 (Bethesda), 2022 Dec 1. PMID 36200850, Free PMC Article
    4. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7506-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7640798..7641648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139887.5 → NP_648144.3  uncharacterized protein Dmel_CG7506 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648144.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95SS8, Q9VS96
      Related
      FBpp0076533
      Conserved Domains (1) summary
      pfam06979
      Location:85 → 206
      TMEM70; Assembly, mitochondrial proton-transport ATP synth complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SS8.1 Q95SS8

    Gene LinkOut

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