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    garz gartenzwerg [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36337, updated on 9-Dec-2024

    Summary

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    Official Symbol
    garzprovided by FlyBase
    Official Full Name
    gartenzwergprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264560
    Locus tag
    Dmel_CG8487
    See related
    AllianceGenome:FB:FBgn0264560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ang; ARF1GEF; ArfGEF; CG 8487; CG8487; Dmel\CG8487; Garz; GBF1; GEF
    Summary
    Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including ARF protein signal transduction; positive regulation of endocytosis; and regulation of tube architecture, open tracheal system. Located in Golgi cis cisterna and cis-Golgi network. Is expressed in several structures, including adult head; gland; gut section; larval tracheal system; and salivary gland body primordium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate A. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See garz in Genome Data Viewer
    Location:
    48F8-48F10; 2-66 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12326360..12333860)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8213865..8221365)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44316 Neighboring gene mitochondrial translation initiation factor 3 Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Histidine-GTG 1-1 Neighboring gene transfer RNA:Histidine-GTG 1-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arf-GEF GBF1 undergoes multi-domain structural shifts to activate Arf at the Golgi. Meissner JM, et al. Front Cell Dev Biol, 2023. PMID 37745300, Free PMC Article
    2. A miRNA screen procedure identifies garz as an essential factor in adult glia functions and validates Drosophila as a beneficial 3Rs model to study glial functions and GBF1 biology. Gonçalves-Pimentel C, et al. F1000Res, 2020. PMID 32595956, Free PMC Article
    3. Sec71 separates Golgi stacks in Drosophila S2 cells. Fujii S, et al. J Cell Sci, 2020 Dec 29. PMID 33262309, Free PMC Article
    4. Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers. Cox R, et al. Mol Biol Cell, 2004 Apr. PMID 14742722, Free PMC Article
    5. Biosynthesis and assembly of the Collagen IV-like protein Pericardin in Drosophila melanogaster. Wilmes AC, et al. Biol Open, 2018 Apr 23. PMID 29685999, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A miRNA screen procedure identifies garz as an essential factor in adult glia functions and validates Drosophila as a beneficial 3Rs model to study glial functions and GBF1 biology.
      Title: A miRNA screen procedure identifies garz as an essential factor in adult glia functions and validates Drosophila as a beneficial 3Rs model to study glial functions and GBF1 biology.
    2. In the absence of functional Garz protein, the integrity of the Golgi complex is impaired and as a result, both vesicle transport of cargo proteins and directed apical membrane delivery are severely disrupted.
      Title: GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis.
    3. garz interacts genetically with the ARF1 homolog ARF79F and with the ARF1-GAP homolog Gap69C, thus placing garz in a regulatory circuit that controls coatomer protein complex I trafficking in Drosophila.
      Title: The Drosophila Sec7 domain guanine nucleotide exchange factor protein Gartenzwerg localizes at the cis-Golgi and is essential for epithelial tube expansion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ARF protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lumen formation, open tracheal system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of tube diameter, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in secretion by cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gartenzwerg
    Names
    CG8487-PA
    CG8487-PB
    CG8487-PC
    angina
    angle wing
    garz-PA
    garz-PB
    garz-PC
    sec7-family GEF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12326360..12333860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136917.4 → NP_610761.2  gartenzwerg, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610761.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8W8
      Related
      FBpp0087010
      Conserved Domains (3) summary
      COG5307
      Location:346 → 1062
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:643 → 830
      Sec7; Sec7 domain
      pfam12783
      Location:370 → 512
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    2. NM_001259349.2 → NP_001246278.1  gartenzwerg, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246278.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7N0
      Conserved Domains (3) summary
      COG5307
      Location:346 → 1062
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:643 → 830
      Sec7; Sec7 domain
      pfam12783
      Location:370 → 512
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

    3. NM_165881.2 → NP_725133.1  gartenzwerg, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8W9
      Related
      FBpp0087011
      Conserved Domains (3) summary
      COG5307
      Location:346 → 1062
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      pfam01369
      Location:643 → 830
      Sec7; Sec7 domain
      pfam12783
      Location:370 → 512
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7N0 A0A0B4K7N0
    A1Z8W8 A1Z8W8
    A1Z8W9 A1Z8W9
    Q8T4A1 Q8T4A1

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