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    Prosbeta4 Proteasome beta4 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosbeta4provided by FlyBase
    Official Full Name
    Proteasome beta4 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032596
    Locus tag
    Dmel_CG17331
    See related
    AllianceGenome:FB:FBgn0032596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    17331; beta-4; Beta-4; beta4; CG17331; Dmel\CG17331; GC17331; Pros beta4; Psmb2; PSMB2
    Summary
    Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and sexual reproduction. Part of proteasome core complex. Is expressed in adult head and adult heart. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosbeta4 in Genome Data Viewer
    Location:
    36A12-36A12; 2-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16731180..16732133, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16731180..16732133, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene uncharacterized protein Neighboring gene NUBP iron-sulfur cluster assembly factor 1 Neighboring gene gluon Neighboring gene Chitin and LDLR binding deacetylase 3 Neighboring gene Like Sm 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy. Ribot C, et al. PLoS Genet, 2022 Jan. PMID 35025870, Free PMC Article
    2. Proteasome Structure and Assembly. Budenholzer L, et al. J Mol Biol, 2017 Nov 10. PMID 28583440, Free PMC Article
    3. Sperm competitive ability in Drosophila melanogaster associated with variation in male reproductive proteins. Fiumera AC, et al. Genetics, 2005 Jan. PMID 15466425, Free PMC Article
    4. Actomyosin contraction during cellularization is regulated in part by Src64 control of Actin 5C protein levels. Carter TY, et al. Genesis, 2019 Jun. PMID 30974046
    5. Identification of the stress granule transcriptome via RNA-editing in single cells and in vivo. van Leeuwen W, et al. Cell Rep Methods, 2022 Jun 20. PMID 35784648, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables peptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome beta4 subunit
    Names
    CG17331-PA
    CG17331-PB
    Prosbeta4-PA
    Prosbeta4-PB
    beta4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16731180..16732133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273582.1 → NP_001260511.1  proteasome beta4 subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260511.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJJ0
      Conserved Domains (2) summary
      COG0638
      Location:1 → 194
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03758
      Location:1 → 192
      proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    2. NM_135960.4 → NP_609804.1  proteasome beta4 subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJJ0
      Related
      FBpp0080490
      Conserved Domains (2) summary
      COG0638
      Location:1 → 194
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03758
      Location:1 → 192
      proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJJ0 Q9VJJ0

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