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    Wnt6 Wnt oncogene analog 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34010, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wnt6provided by FlyBase
    Official Full Name
    Wnt oncogene analog 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0031902
    Locus tag
    Dmel_CG4969
    See related
    AllianceGenome:FB:FBgn0031902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4969; D-Wnt-6; Dmel\CG4969; Dwnt-6; DWnt-6; Dwnt6; DWnt6; wnt6
    Summary
    Predicted to enable cytokine activity and frizzled binding activity. Involved in canonical Wnt signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cuboidal/columnar epithelium; dorsal-ventral compartment boundary of the wing disc; embryonic foregut; imaginal disc; and maxillary palp. Orthologous to human WNT6 (Wnt family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Wnt6 in Genome Data Viewer
    Location:
    27F1-27F2; 2-26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7333714..7352542)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7333714..7352542)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene wingless Neighboring gene long non-coding RNA:CR45304 Neighboring gene antisense RNA:CR44063 Neighboring gene Wnt oncogene analog 10 Neighboring gene neither inactivation nor afterpotential C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gain of cis-regulatory activities underlies novel domains of wingless gene expression in Drosophila. Koshikawa S, et al. Proc Natl Acad Sci U S A, 2015 Jun 16. PMID 26034272, Free PMC Article
    2. Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche. Wang X, et al. Development, 2018 Feb 7. PMID 29361569, Free PMC Article
    3. Wnt gene regulation and function during maxillary palp development in Drosophila melanogaster. Holzem M, et al. Dev Biol, 2020 Jun 1. PMID 32229133
    4. Expression of DWnt6, DWnt10, and DFz4 during Drosophila development. Janson K, et al. Mech Dev, 2001 May. PMID 11335117
    5. Wnt6 is required for maxillary palp formation in Drosophila. Doumpas N, et al. BMC Biol, 2013 Oct 3. PMID 24090348, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wnt6 regulates the homeostasis of the stem cell niche via Rac1-and Cdc42-mediated noncanonical Wnt signalling pathways in Drosophila testis.
      Title: Wnt6 regulates the homeostasis of the stem cell niche via Rac1-and Cdc42-mediated noncanonical Wnt signalling pathways in Drosophila testis.
    2. Anterior escort cells are maintained by Wnt6 ligands produced by cap cells; without Wnt6 signaling, anterior escort cells die leaving vacancies in the niche, leading to loss of germline stem cells.
      Title: Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche.
    3. Wnt6 is important for maxillary palp development in Drosophila, and phylogenetic analysis indicates that loss of Wnt6 may also have led to loss of maxillary palps on an evolutionary time scale.
      Title: Wnt6 is required for maxillary palp formation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 7343381-7350438 mobile_element_type = transposon:roo{}319

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Wnt oncogene analog 6
    Names
    CG4969-PB
    CG4969-PC
    Wnt6-PB
    Wnt6-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7333714..7352542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135264.4 → NP_609108.3  Wnt oncogene analog 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609108.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2J621, Q9VM26
      Conserved Domains (1) summary
      pfam00110
      Location:41 → 419
      wnt; wnt family

    2. NM_001273259.1 → NP_001260188.1  Wnt oncogene analog 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G2J621, Q9VM26
      Conserved Domains (1) summary
      pfam00110
      Location:41 → 419
      wnt; wnt family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM26 Q9VM26

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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