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    SCCRO4 Squamous cell carcinoma-related oncogene 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCCRO4provided by FlyBase
    Official Full Name
    Squamous cell carcinoma-related oncogene 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0036967
    Locus tag
    Dmel_CG6597
    See related
    AllianceGenome:FB:FBgn0036967
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6597; Dmel\CG6597; dSCCRO4
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Involved in negative regulation of protein neddylation. Located in nucleus. Is expressed in organism. Orthologous to human DCUN1D4 (defective in cullin neddylation 1 domain containing 4) and DCUN1D5 (defective in cullin neddylation 1 domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SCCRO4 in Genome Data Viewer
    Location:
    77B2-77B2; 3-47 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20299410..20309511)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20292510..20302611)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene golden goal Neighboring gene long non-coding RNA:CR43890 Neighboring gene antisense RNA:CR43872 Neighboring gene FSHD region gene 1 Neighboring gene Peroxin 23 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43875 Neighboring gene polo Neighboring gene alpha Soluble NSF attachment protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Squamous Cell Carcinoma-related Oncogene (SCCRO) Family Members Regulate Cell Growth and Proliferation through Their Cooperative and Antagonistic Effects on Cullin Neddylation. Fu W, et al. J Biol Chem, 2016 Mar 18. PMID 26792857, Free PMC Article
    2. Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing. Mazloomian A, et al. RNA Biol, 2015. PMID 26512413, Free PMC Article
    3. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
    4. Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis. Lin WH, et al. Dis Model Mech, 2017 Feb 1. PMID 28067623, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    squamous cell carcinoma-related oncogene 4
    Names
    CG6597-PA
    CG6597-PB
    CG6597-PD
    CG6597-PE
    SCCRO4-PA
    SCCRO4-PB
    SCCRO4-PD
    SCCRO4-PE
    squamous cell carcinoma-related oncogene 4 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20299410..20309511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300198.1 → NP_001287127.1  squamous cell carcinoma-related oncogene 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287127.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWB1
      Conserved Domains (1) summary
      pfam03556
      Location:123 → 234
      Cullin_binding; Cullin binding

    2. NM_168842.2 → NP_730510.2  squamous cell carcinoma-related oncogene 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730510.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWB1
      Related
      FBpp0074607
      Conserved Domains (1) summary
      pfam03556
      Location:123 → 234
      Cullin_binding; Cullin binding

    3. NM_140947.4 → NP_649204.2  squamous cell carcinoma-related oncogene 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649204.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWB1
      Related
      FBpp0074606
      Conserved Domains (1) summary
      pfam03556
      Location:123 → 234
      Cullin_binding; Cullin binding

    4. NM_001202210.3 → NP_001189139.2  squamous cell carcinoma-related oncogene 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189139.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRX5
      Conserved Domains (1) summary
      pfam03556
      Location:88 → 199
      Cullin_binding; Cullin binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRX5 M9MRX5
    Q9VWB1 Q9VWB1
    Q9VWB1.2

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