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    CG5989 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38984, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG5989provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0017429
    Locus tag
    Dmel_CG5989
    See related
    AllianceGenome:FB:FBgn0017429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-66Db; Dmel\CG5989
    Summary
    Predicted to enable potassium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; longitudinal visceral muscle fiber; and somatic trunk mesoderm derivative. Orthologous to human LETMD1 (LETM1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5989 in Genome Data Viewer
    Location:
    66D8-66D8; 3-26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8602411..8604149, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8595511..8597249, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein L14 Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila ribosomal protein L14-encoding gene, identified by a novel Minute mutation in a dense cluster of previously undescribed genes in cytogenetic region 66D. Saebøe-Larssen S, et al. Mol Gen Genet, 1997 Jun. PMID 9236770
    2. Conservation of gene order, structure and sequence between three closely linked genes in Drosophila melanogaster and Drosophila virilis. Lyamouri M, et al. Gene, 2002 Jan 9. PMID 11814692
    3. Selection on codon usage in Drosophila americana. Maside X, et al. Curr Biol, 2004 Jan 20. PMID 14738738
    4. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article
    5. Unraveling the Genetic Basis for the Rapid Diversification of Male Genitalia between Drosophila Species. Hagen JFD, et al. Mol Biol Evol, 2021 Jan 23. PMID 32931587, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables potassium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5989-PA
    CG5989-PB
    CG5989-PC
    SAM methionine methyltransferase
    anonymous-66Db

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8602411..8604149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274665.1 → NP_001261594.1  uncharacterized protein Dmel_CG5989, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261594.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF10, P91617
      Conserved Domains (1) summary
      pfam07766
      Location:139 → 392
      LETM1; LETM1-like protein

    2. NM_001274664.1 → NP_001261593.1  uncharacterized protein Dmel_CG5989, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261593.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEJ9, P91617
      Conserved Domains (1) summary
      pfam07766
      Location:148 → 401
      LETM1; LETM1-like protein

    3. NM_139985.4 → NP_648242.1  uncharacterized protein Dmel_CG5989, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91617, Q9VSM4
      Related
      FBpp0076373
      Conserved Domains (1) summary
      pfam07766
      Location:150 → 403
      LETM1; LETM1-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEJ9 M9PEJ9
    M9PF10 M9PF10
    P91616 P91616
    P91617 P91617
    Q9VSM4 Q9VSM4

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