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    CG3328 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3328provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034985
    Locus tag
    Dmel_CG3328
    See related
    AllianceGenome:FB:FBgn0034985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3328
    Summary
    Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and protein autoprocessing. Predicted to be active in endoplasmic reticulum membrane and nucleus. Is expressed in several structures, including embryonic anal pad; embryonic hindgut; embryonic large intestine; embryonic ventral epidermis; and embryonic/larval garland cell. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; hyperopia; nanophthalmos; and primary angle-closure glaucoma. Orthologous to human MYRF (myelin regulatory factor) and MYRFL (myelin regulatory factor like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3328 in Genome Data Viewer
    Location:
    60C1-60C1; 2-106 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24162489..24173660)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20050012..20061183)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene speck Neighboring gene DnaJ-like-60 Neighboring gene uncharacterized protein Neighboring gene spaghetti Neighboring gene ncRNA Neighboring gene mitochondrial ribosomal protein S17 Neighboring gene Nucleolar protein at 60B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dorsoventral patterning of the Drosophila hindgut is determined by interaction of genes under the control of two independent gene regulatory systems, the dorsal and terminal systems. Hamaguchi T, et al. Mech Dev, 2012 Sep-Dec. PMID 22898294
    2. Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes. Zhang S, et al. Genes (Basel), 2021 Oct 12. PMID 34681000, Free PMC Article
    3. Drosophila Spag is the homolog of RNA polymerase II-associated protein 3 (RPAP3) and recruits the heat shock proteins 70 and 90 (Hsp70 and Hsp90) during the assembly of cellular machineries. Benbahouche Nel H, et al. J Biol Chem, 2014 Feb 28. PMID 24394412, Free PMC Article
    4. The Extracellular and Cytoplasmic Domains of Syndecan Cooperate Postsynaptically to Promote Synapse Growth at the Drosophila Neuromuscular Junction. Nguyen MU, et al. PLoS One, 2016. PMID 26987116, Free PMC Article
    5. The exoribonuclease Nibbler controls 3' end processing of microRNAs in Drosophila. Liu N, et al. Curr Biol, 2011 Nov 22. PMID 22055292, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoprocessing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3328-PA
    CG3328-PB
    CG3328-PC
    CG3328-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24162489..24173660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382064.1 → NP_001369116.1  uncharacterized protein Dmel_CG3328, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL96, Q9W1A0
      Conserved Domains (2) summary
      cd10144
      Location:607 → 729
      Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
      pfam05224
      Location:413 → 560
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family

    2. NM_001299900.1 → NP_001286829.1  uncharacterized protein Dmel_CG3328, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286829.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL96, Q9W1A0
      Conserved Domains (2) summary
      cd10144
      Location:607 → 729
      Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
      pfam05224
      Location:413 → 560
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family

    3. NM_138049.3 → NP_611893.3  uncharacterized protein Dmel_CG3328, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611893.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL96, Q9W1A0
      Related
      FBpp0072165
      Conserved Domains (2) summary
      cd10144
      Location:607 → 729
      Peptidase_S74_CIMCD; Peptidase S74 family, C-terminal intramolecular chaperone domain of Escherichia coli phage K1F endosialidase and related proteins
      pfam05224
      Location:413 → 560
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family

    4. NM_001299901.1 → NP_001286830.1  uncharacterized protein Dmel_CG3328, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGG8, Q6NL96
      Conserved Domains (3) summary
      pfam05224
      Location:413 → 560
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:607 → 672
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:692 → 727
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGG8 A0A0B4LGG8
    Q8SXA0 Q8SXA0
    Q9W1A0 Q9W1A0

    Gene LinkOut

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