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    srw shrew [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    srwprovided by FlyBase
    Official Full Name
    shrewprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261952
    Locus tag
    Dmel_CG11582
    See related
    AllianceGenome:FB:FBgn0261952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11582; Dmel\CG11582
    Summary
    Involved in amnioserosa formation; dorsal/ventral pattern formation; and positive regulation of BMP signaling pathway. Predicted to be active in extracellular space. Orthologous to human TWSG1 (twisted gastrulation BMP signaling modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See srw in Genome Data Viewer
    Location:
    64A12-64A12; 3-10 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4282956..4283478, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4282956..4283478, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Choline transporter-like 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Transcription factor IIEbeta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered mitotic domains reveal fate map changes in Drosophila embryos mutant for zygotic dorsoventral patterning genes. Arora K, et al. Development, 1992 Apr. PMID 1618145
    2. Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo. Ferguson EL, et al. Development, 1992 Mar. PMID 1618130
    3. A common plan for dorsoventral patterning in Bilateria. De Robertis EM, et al. Nature, 1996 Mar 7. PMID 8598900
    4. Rapid evolution of a novel signalling mechanism by concerted duplication and divergence of a BMP ligand and its extracellular modulators. Fritsch C, et al. Dev Genes Evol, 2010 Dec. PMID 21086136
    5. Dorsoventral development of the Drosophila embryo is controlled by a cascade of transcriptional regulators. Thisse C, et al. Dev Suppl, 1992. PMID 1299363

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in amnioserosa formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    shrew
    Names
    CG11582-PB
    srw-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4282956..4283478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139629.3 → NP_647886.2  shrew [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647886.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZE5
      Conserved Domains (1) summary
      pfam04668
      Location:26 → 127
      Tsg; Twisted gastrulation (Tsg) protein conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZE5 Q9VZE5

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