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    Arms Ankyrin repeat-rich membrane spanning [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37433, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Armsprovided by FlyBase
    Official Full Name
    Ankyrin repeat-rich membrane spanningprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261554
    Locus tag
    Dmel_CG42672
    See related
    AllianceGenome:FB:FBgn0261554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ARMS; CG10074; CG15665; CG30386; CG30387; CG42672; dARMS; Dmel\CG42672; KIDINS220
    Old locus tag
    Dmel_CG30386; Dmel_CG30387
    Summary
    Predicted to enable protein kinase regulator activity. Predicted to be involved in nerve growth factor signaling pathway. Is expressed in adult head. Orthologous to human KIDINS220 (kinase D interacting substrate 220). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arms in Genome Data Viewer
    Location:
    57D8-57D11; 2-94 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21295652..21310411)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17183157..17197916)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene SAGA-associated factor 29kDa Neighboring gene Ribosomal protein L29 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44724 Neighboring gene antisense RNA:CR45149 Neighboring gene Panoramix Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ARMS-NF-κB signaling regulates intracellular ROS to induce autophagy-associated cell death upon oxidative stress. Liao YH, et al. iScience, 2023 Feb 17. PMID 36798436, Free PMC Article
    2. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
    3. The genetic basis of incipient sexual isolation in Drosophila melanogaster. Yamamoto A, et al. Proc Biol Sci, 2024 Aug. PMID 39045689, Free PMC Article
    4. In Depth Exploration of the Alternative Proteome of Drosophila melanogaster. Fabre B, et al. Front Cell Dev Biol, 2022. PMID 35721519, Free PMC Article
    5. Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster. Harbison ST, et al. Behav Genet, 2019 Jan. PMID 30341464, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nerve growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat-rich membrane spanning
    Names
    Arms-PD
    Arms-PF
    Arms-PG
    Arms-PI
    Arms-PJ
    Arms-PK
    Arms-PL
    Arms-PM
    Arms-PO
    Arms-PP
    Arms-PQ
    Arms-PR
    Arms-PS
    Arms-PT
    Arms-PU
    Arms-PV
    CG42672-PD
    CG42672-PF
    CG42672-PG
    CG42672-PI
    CG42672-PJ
    CG42672-PK
    CG42672-PL
    CG42672-PM
    CG42672-PO
    CG42672-PP
    CG42672-PQ
    CG42672-PR
    CG42672-PS
    CG42672-PT
    CG42672-PU
    CG42672-PV

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21295652..21310411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166441.4 → NP_726059.5  ankyrin repeat-rich membrane spanning, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726059.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2I0
      Conserved Domains (7) summary
      cd09487
      Location:1357 → 1392
      SAM_superfamily; SAM (Sterile alpha motif )
      cd00204
      Location:231 → 355
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:605 → 1136
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:240 → 332
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:401 → 454
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:518 → 575
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:235 → 266
      ANK; ANK repeat [structural motif]

    2. NM_001299745.1 → NP_001286674.1  ankyrin repeat-rich membrane spanning, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH32
      Conserved Domains (7) summary
      cd09487
      Location:1193 → 1228
      SAM_superfamily; SAM (Sterile alpha motif )
      cd00204
      Location:67 → 191
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:441 → 972
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:76 → 168
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:237 → 290
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:354 → 411
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:71 → 102
      ANK; ANK repeat [structural motif]

    3. NM_001169762.2 → NP_001163233.1  ankyrin repeat-rich membrane spanning, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163233.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGQ4
      Conserved Domains (7) summary
      cd09487
      Location:1193 → 1228
      SAM_superfamily; SAM (Sterile alpha motif )
      cd00204
      Location:67 → 191
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:441 → 972
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:76 → 168
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:237 → 290
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:354 → 411
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:71 → 102
      ANK; ANK repeat [structural motif]

    4. NM_137730.4 → NP_611574.5  ankyrin repeat-rich membrane spanning, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611574.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVP6
      Conserved Domains (7) summary
      cd09487
      Location:1357 → 1392
      SAM_superfamily; SAM (Sterile alpha motif )
      cd00204
      Location:231 → 355
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:605 → 1136
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:240 → 332
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:401 → 454
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:518 → 575
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:235 → 266
      ANK; ANK repeat [structural motif]

    5. NM_001144252.3 → NP_001137724.1  ankyrin repeat-rich membrane spanning, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZM7
      Conserved Domains (7) summary
      cd09487
      Location:1193 → 1228
      SAM_superfamily; SAM (Sterile alpha motif )
      COG0666
      Location:320 → 441
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:67 → 191
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:441 → 972
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:76 → 168
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:237 → 290
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:71 → 102
      ANK; ANK repeat [structural motif]

    6. NM_001382092.1 → NP_001369103.1  ankyrin repeat-rich membrane spanning, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q9J1
      Conserved Domains (6) summary
      PTZ00322
      Location:24 → 112
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd09487
      Location:1208 → 1243
      SAM_superfamily; SAM (Sterile alpha motif )
      PHA03095
      Location:70 → 345
      PHA03095; ankyrin-like protein; Provisional
      pfam07693
      Location:456 → 987
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:86 → 117
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:325 → 404
      Ank_2; Ankyrin repeats (3 copies)

    7. NM_001382093.1 → NP_001369104.1  ankyrin repeat-rich membrane spanning, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q8I0
      Conserved Domains (5) summary
      PHA02874
      Location:89 → 456
      PHA02874; ankyrin repeat protein; Provisional
      cd09487
      Location:1208 → 1243
      SAM_superfamily; SAM (Sterile alpha motif )
      COG0666
      Location:2 → 143
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      pfam07693
      Location:456 → 987
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:86 → 117
      ANK; ANK repeat [structural motif]

    8. NM_001382090.1 → NP_001369101.1  ankyrin repeat-rich membrane spanning, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q8E0
      Conserved Domains (6) summary
      PTZ00322
      Location:49 → 137
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd09487
      Location:1233 → 1268
      SAM_superfamily; SAM (Sterile alpha motif )
      PHA03095
      Location:95 → 370
      PHA03095; ankyrin-like protein; Provisional
      pfam07693
      Location:481 → 1012
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:111 → 142
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:350 → 429
      Ank_2; Ankyrin repeats (3 copies)

    9. NM_001382091.1 → NP_001369102.1  ankyrin repeat-rich membrane spanning, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3QHD0
      Conserved Domains (5) summary
      PHA02874
      Location:114 → 481
      PHA02874; ankyrin repeat protein; Provisional
      cd09487
      Location:1233 → 1268
      SAM_superfamily; SAM (Sterile alpha motif )
      COG0666
      Location:29 → 168
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      pfam07693
      Location:481 → 1012
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:111 → 142
      ANK; ANK repeat [structural motif]

    10. NM_166442.3 → NP_726060.3  ankyrin repeat-rich membrane spanning, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726060.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVP5
      Conserved Domains (7) summary
      cd09487
      Location:1267 → 1302
      SAM_superfamily; SAM (Sterile alpha motif )
      cd00204
      Location:141 → 265
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:515 → 1046
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:150 → 242
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:311 → 364
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:428 → 485
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:145 → 176
      ANK; ANK repeat [structural motif]

    11. NM_001144253.2 → NP_001137725.1  ankyrin repeat-rich membrane spanning, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZM5
      Conserved Domains (7) summary
      cd09487
      Location:1267 → 1302
      SAM_superfamily; SAM (Sterile alpha motif )
      cd00204
      Location:141 → 265
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:515 → 1046
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:150 → 242
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:311 → 364
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:428 → 485
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:145 → 176
      ANK; ANK repeat [structural motif]

    12. NM_001144251.3 → NP_001137723.2  ankyrin repeat-rich membrane spanning, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137723.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZM3
      Conserved Domains (7) summary
      cd09487
      Location:1215 → 1250
      SAM_superfamily; SAM (Sterile alpha motif )
      cd00204
      Location:89 → 213
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:463 → 994
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:98 → 190
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:259 → 312
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:376 → 433
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:93 → 124
      ANK; ANK repeat [structural motif]

    13. NM_001144254.3 → NP_001137726.1  ankyrin repeat-rich membrane spanning, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137726.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZM6
      Conserved Domains (7) summary
      cd09487
      Location:1215 → 1250
      SAM_superfamily; SAM (Sterile alpha motif )
      cd00204
      Location:89 → 213
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:463 → 994
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:98 → 190
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:259 → 312
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:376 → 433
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:93 → 124
      ANK; ANK repeat [structural motif]

    14. NM_001382094.1 → NP_001369105.1  ankyrin repeat-rich membrane spanning, isoform U [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3QHJ1
      Conserved Domains (6) summary
      cd09487
      Location:1233 → 1268
      SAM_superfamily; SAM (Sterile alpha motif )
      PHA03095
      Location:95 → 370
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:16 → 168
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      pfam07693
      Location:481 → 1012
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:111 → 142
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:350 → 429
      Ank_2; Ankyrin repeats (3 copies)

    15. NM_001144250.2 → NP_001137722.2  ankyrin repeat-rich membrane spanning, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137722.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZM4
      Conserved Domains (7) summary
      cd09487
      Location:1233 → 1268
      SAM_superfamily; SAM (Sterile alpha motif )
      cd00204
      Location:107 → 231
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07693
      Location:481 → 1012
      KAP_NTPase; KAP family P-loop domain
      pfam12796
      Location:116 → 208
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:277 → 330
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:394 → 451
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:111 → 142
      ANK; ANK repeat [structural motif]

    16. NM_001382095.1 → NP_001369106.1  ankyrin repeat-rich membrane spanning, isoform V [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q832
      Conserved Domains (5) summary
      PHA02874
      Location:114 → 481
      PHA02874; ankyrin repeat protein; Provisional
      cd09487
      Location:1233 → 1268
      SAM_superfamily; SAM (Sterile alpha motif )
      COG0666
      Location:16 → 168
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      pfam07693
      Location:481 → 1012
      KAP_NTPase; KAP family P-loop domain
      sd00045
      Location:111 → 142
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH32 A0A0B4LH32
    A0A6M3Q832 A0A6M3Q832
    A0A6M3Q8E0 A0A6M3Q8E0
    A0A6M3Q8I0 A0A6M3Q8I0
    A0A6M3Q9J1 A0A6M3Q9J1
    A0A6M3QHD0 A0A6M3QHD0
    A0A6M3QHJ1 A0A6M3QHJ1
    B7YZM3 B7YZM3
    B7YZM4 B7YZM4
    B7YZM5 B7YZM5
    B7YZM6 B7YZM6
    B7YZM7 B7YZM7
    E1JGQ4 E1JGQ4
    Q7KVP5 Q7KVP5
    Q7KVP6 Q7KVP6
    Q7YU92 Q7YU92
    Q9W2I0 Q9W2I0

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