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    Pde8 Phosphodiesterase 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pde8provided by FlyBase
    Official Full Name
    Phosphodiesterase 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0266377
    Locus tag
    Dmel_CG45019
    See related
    AllianceGenome:FB:FBgn0266377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG42241; CG45019; CG5411; Dmel\CG45019; pde8; PDE8
    Old locus tag
    Dmel_CG42241; Dmel_CG5411
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in mesoderm development and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including adult fat body; adult head; embryonic anal pad; gut section; and salivary gland body primordium. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 3. Orthologous to human PDE8A (phosphodiesterase 8A) and PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pde8 in Genome Data Viewer
    Location:
    59F5-59F6; 2-104 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23657567..23680844)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19545090..19568367)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Entomoglyceroporin 2 Neighboring gene Entomoglyceroporin 4 Neighboring gene long non-coding RNA:CR45153 Neighboring gene retained Neighboring gene lethal (2) essential for life Neighboring gene Sulfotransferase 1 Neighboring gene Sulfotransferase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila. Choi C, et al. Cell Rep, 2012 Aug 30. PMID 22938867, Free PMC Article
    2. Translation of CircRNAs. Pamudurti NR, et al. Mol Cell, 2017 Apr 6. PMID 28344080, Free PMC Article
    3. Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Day JP, et al. Biochem J, 2005 May 15. PMID 15673286, Free PMC Article
    4. Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Brown KM, et al. Proc Natl Acad Sci U S A, 2013 Apr 16. PMID 23509299, Free PMC Article
    5. White - cGMP Interaction Promotes Fast Locomotor Recovery from Anoxia in Adult Drosophila. Xiao C, et al. PLoS One, 2017. PMID 28060942, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP metabolic process ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphodiesterase 8
    Names
    CG45019-PA
    CG45019-PB
    CG45019-PC
    CG45019-PD
    CG45019-PE
    CG45019-PI
    CG45019-PK
    CG45019-PN
    CG45019-PO
    CG45019-PP
    CG45019-PQ
    CG45019-PR
    Pde8-PA
    Pde8-PB
    Pde8-PC
    Pde8-PD
    Pde8-PE
    Pde8-PI
    Pde8-PK
    Pde8-PN
    Pde8-PO
    Pde8-PP
    Pde8-PQ
    Pde8-PR
    NP_001163274.1
    NP_001163275.2
    NP_001163276.1
    NP_001163278.2
    NP_001400989.1
    NP_001401020.1
    NP_001401021.1
    NP_611814.3
    NP_726350.1
    NP_726351.1
    NP_726352.1
    NP_726353.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23657567..23680844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166616.3 → NP_726350.1  phosphodiesterase 8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGU3, Q5BI98, Q6NNF2, Q8MLR0, Q95T53, Q9W1L9
      Related
      FBpp0310592
      Conserved Domains (2) summary
      pfam00233
      Location:639 → 871
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:327 → 403
      PAS_9; PAS domain

    2. NM_001169807.2 → NP_001163278.2  phosphodiesterase 8, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163278.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JGU6
      Conserved Domains (3) summary
      cd00130
      Location:323 → 403
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:639 → 880
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:327 → 403
      PAS_9; PAS domain

    3. NM_137970.5 → NP_611814.3  phosphodiesterase 8, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611814.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NNF2
      Conserved Domains (2) summary
      pfam00233
      Location:630 → 862
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:327 → 403
      PAS_9; PAS domain

    4. NM_001169803.2 → NP_001163274.1  phosphodiesterase 8, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGU3, Q5BI98, Q6NNF2, Q8MLR0, Q95T53, Q9W1L9
      Conserved Domains (2) summary
      pfam00233
      Location:639 → 871
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:327 → 403
      PAS_9; PAS domain

    5. NM_001414110.1 → NP_001400989.1  phosphodiesterase 8, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PDF0

    6. NM_001169805.2 → NP_001163276.1  phosphodiesterase 8, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163276.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JGU3, Q5BI98, Q6NNF2, Q8MLR0, Q95T53, Q9W1L9
      Conserved Domains (2) summary
      pfam00233
      Location:639 → 871
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:327 → 403
      PAS_9; PAS domain

    7. NM_001414112.1 → NP_001401021.1  phosphodiesterase 8, isoform R [Drosophila melanogaster]

      Status: REVIEWED

    8. NM_001414111.1 → NP_001401020.1  phosphodiesterase 8, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

    9. NM_166618.3 → NP_726352.1  phosphodiesterase 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726352.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NNF2
      Related
      FBpp0310591
      Conserved Domains (3) summary
      cd00130
      Location:313 → 393
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:629 → 870
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:317 → 393
      PAS_9; PAS domain

    10. NM_166617.2 → NP_726351.1  phosphodiesterase 8, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726351.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLR1
      Related
      FBpp0310589
      Conserved Domains (3) summary
      cd00130
      Location:214 → 294
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:530 → 771
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:218 → 294
      PAS_9; PAS domain

    11. NM_001169804.2 → NP_001163275.2  phosphodiesterase 8, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163275.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NNF2
      Conserved Domains (3) summary
      cd00130
      Location:459 → 539
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:775 → 1016
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:463 → 539
      PAS_9; PAS domain

    12. NM_166619.2 → NP_726353.1  phosphodiesterase 8, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726353.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NNF2
      Related
      FBpp0310588
      Conserved Domains (1) summary
      pfam00233
      Location:125 → 366
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JGU6 E1JGU6
    Q6NNF2.1 Q6NNF2
    Q8IGT9 Q8IGT9
    Q8MLR1 Q8MLR1

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