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    alphaSnap alpha Soluble NSF attachment protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alphaSnapprovided by FlyBase
    Official Full Name
    alpha Soluble NSF attachment proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250791
    Locus tag
    Dmel_CG6625
    See related
    AllianceGenome:FB:FBgn0250791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    a-Snap; alpha-snap; alpha-Snap; alpha-SNAP; alphaSNAP; aSnap; CG6625; dalpha-SNAP; dalphaSNAP; Dmel\CG6625; dsnap; dSNAP; l(3)77ABa; l(3)77ABc; snap; Snap; SNAP; SnapII
    Summary
    Enables SNARE binding activity and soluble NSF attachment protein activity. Involved in several processes, including SNARE complex disassembly; chemical synaptic transmission; and imaginal disc-derived wing expansion. Located in cytoplasmic vesicle; membrane; and terminal bouton. Is expressed in several structures, including adult head; adult heart; brain; larval nervous system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 107. Orthologous to human NAPA (NSF attachment protein alpha) and NAPB (NSF attachment protein beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alphaSnap in Genome Data Viewer
    Location:
    77B3-77B3; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20313632..20316577)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20306732..20309677)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Squamous cell carcinoma-related oncogene 4 Neighboring gene uncharacterized protein Neighboring gene polo Neighboring gene antisense RNA:CR43875 Neighboring gene Serpin 77Ba Neighboring gene Serpin 77Bb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neurally expressed Drosophila genes encoding homologs of the NSF and SNAP secretory proteins. Ordway RW, et al. Proc Natl Acad Sci U S A, 1994 Jun 7. PMID 8202553, Free PMC Article
    2. An essential and NSF independent role for α-SNAP in store-operated calcium entry. Miao Y, et al. Elife, 2013 Jul 16. PMID 23878724, Free PMC Article
    3. Quantifying Glial-Glial Tiling Using Automated Image Analysis in Drosophila. Salazar G, et al. Front Cell Neurosci, 2022. PMID 35401121, Free PMC Article
    4. Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. Muller JM, et al. J Cell Biol, 2002 Jun 24. PMID 12070132, Free PMC Article
    5. Syntaxin 5 is required for cytokinesis and spermatid differentiation in Drosophila. Xu H, et al. Dev Biol, 2002 Nov 15. PMID 12435359

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that NSF and SNAP exhibit activity-dependent binding to each other within living presynaptic terminals as well as distinctive interactions and mobilities.
      Title: Activity-dependent interactions of NSF and SNAP at living synapses.
    2. Our results indicate that SNAP promotes neurotransmitter release and SNARE complex disassembly but inhibits secretion when present at high abundance relative to NSF
      Title: Genetic analysis of soluble N-ethylmaleimide-sensitive factor attachment protein function in Drosophila reveals positive and negative secretory roles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables soluble NSF attachment protein activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables soluble NSF attachment protein activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables soluble NSF attachment protein activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables soluble NSF attachment protein activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SNARE complex disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SNARE complex disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing expansion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle priming NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha soluble NSF attachment protein
    Names
    CG6625-PA
    alphaSnap-PA
    lethal (3) 77ABa
    lethal (3) 77ABc
    soluble N-ethylmaleimide-sensitive factor attachment protein
    soluble NSF attachment protein
    soluble NSF-attachment protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20313632..20316577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079456.4 → NP_524180.1  alpha soluble NSF attachment protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524180.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23983, Q541G5
      Related
      FBpp0074609
      Conserved Domains (2) summary
      cd15832
      Location:7 → 284
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
      pfam14938
      Location:7 → 284
      SNAP; Soluble NSF attachment protein, SNAP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23983.1 Q23983

    Gene LinkOut

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    Chemical Information
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