Ogdh Oxoglutarate dehydrogenase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ogdhprovided by FlyBase
Official Full Name: Oxoglutarate dehydrogenaseprovided by FlyBase
Primary source: FLYBASE:FBgn0010352
Locus tag: Dmel_CG11661
See related: AllianceGenome:FB:FBgn0010352
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 141810_at; alpha-KGDH-E1; anon-WO0118547.329; CG11661; Dmel\CG11661; dOgdh; DOGDH; E1; Nc73eF; Nc73EF; OGDH
Summary: Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in intracellular amino acid homeostasis and tricarboxylic acid cycle. Located in Z disc. Is active in mitochondrial matrix. Is expressed in several structures, including adult head; adult heart; anterior endoderm; anterior endoderm anlage; and embryonic/larval midgut primordium. Used to study Yoon-Bellen neurodevelopmental syndrome; dilated cardiomyopathy; and oxoglutarate dehydrogenase deficiency. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome and oxoglutarate dehydrogenase deficiency. Orthologous to several human genes including OGDH (oxoglutarate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 73E1-73E1; 3-45 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16954822..16968724)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16947922..16961824)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities.
Title: Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA Inferred from Electronic Annotation more info
contributes_to oxoglutarate dehydrogenase (NAD+) activity	NAS Non-traceable Author Statement more info	PubMed
enables oxoglutarate dehydrogenase (succinyl-transferring) activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxoglutarate dehydrogenase (succinyl-transferring) activity	ISS Inferred from Sequence or Structural Similarity more info
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular amino acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of oxoglutarate dehydrogenase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of oxoglutarate dehydrogenase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of oxoglutarate dehydrogenase complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: oxoglutarate dehydrogenase

Names: CG11661-PA; CG11661-PB; CG11661-PC; CG11661-PF; CG11661-PG; CG11661-PH; CG11661-PI; CG11661-PJ; CG11661-PK; Ogdh-PA; Ogdh-PB; Ogdh-PC; Ogdh-PF; Ogdh-PG; Ogdh-PH; Ogdh-PI; Ogdh-PJ; Ogdh-PK; alpha-ketoglutarate dehydrogenase E1 subunit; at 73EF; neural conserved; neural conserved at 73EF; neural conserved at 73KF

NP_001097629.1

EC 1.2.4.-

EC 1.2.4.2

NP_001401039.1

EC 1.2.4.-

EC 1.2.4.2

NP_730223.1

EC 1.2.4.-

EC 1.2.4.2

NP_730224.1

EC 1.2.4.-

EC 1.2.4.2

NP_730225.1

EC 1.2.4.-

EC 1.2.4.2

NP_730226.3

EC 1.2.4.-

EC 1.2.4.2

NP_788518.1

EC 1.2.4.-

EC 1.2.4.2

NP_788519.1

EC 1.2.4.-

EC 1.2.4.2

NP_788520.2

EC 1.2.4.-

EC 1.2.4.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

16954822..16968724

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168704.4 → NP_730226.3 oxoglutarate dehydrogenase, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730226.3

Status: REVIEWED

UniProtKB/TrEMBL

A8JNU6

Conserved Domains (5) summary

PRK09404
Location:53 → 1104

sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

cd02016
Location:259 → 521

TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...

pfam02779
Location:645 → 856

Transket_pyr; Transketolase, pyrimidine binding domain

pfam16078
Location:51 → 86

2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus

pfam16870
Location:863 → 1102

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
NM_168703.5 → NP_730225.1 oxoglutarate dehydrogenase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730225.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VVC5

Related

FBpp0075023

Conserved Domains (5) summary

PRK09404
Location:53 → 1007

sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

cd02016
Location:259 → 521

TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...

pfam02779
Location:645 → 856

Transket_pyr; Transketolase, pyrimidine binding domain

pfam16078
Location:51 → 86

2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus

pfam16870
Location:863 → 1005

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
NM_176340.3 → NP_788518.1 oxoglutarate dehydrogenase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788518.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQQ0

Related

FBpp0075027

Conserved Domains (6) summary

PRK09404
Location:53 → 1016

sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

cd02016
Location:268 → 530

TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...

pfam02779
Location:654 → 865

Transket_pyr; Transketolase, pyrimidine binding domain

pfam16078
Location:51 → 86

2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus

pfam16870
Location:872 → 1014

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

cl06123
Location:178 → 226

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
NM_176341.3 → NP_788519.1 oxoglutarate dehydrogenase, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788519.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VVC5

Related

FBpp0075028

Conserved Domains (5) summary

PRK09404
Location:53 → 1007

sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

cd02016
Location:259 → 521

TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...

pfam02779
Location:645 → 856

Transket_pyr; Transketolase, pyrimidine binding domain

pfam16078
Location:51 → 86

2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus

pfam16870
Location:863 → 1005

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
NM_168702.2 → NP_730224.1 oxoglutarate dehydrogenase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730224.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VVC5

Related

FBpp0075024

Conserved Domains (5) summary

PRK09404
Location:53 → 1007

sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

cd02016
Location:259 → 521

TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...

pfam02779
Location:645 → 856

Transket_pyr; Transketolase, pyrimidine binding domain

pfam16078
Location:51 → 86

2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus

pfam16870
Location:863 → 1005

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
NM_001414057.1 → NP_001401039.1 oxoglutarate dehydrogenase, isoform K [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A9F2H0Z0
NM_168701.5 → NP_730223.1 oxoglutarate dehydrogenase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730223.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VVC5

Related

FBpp0075026

Conserved Domains (5) summary

PRK09404
Location:53 → 1007

sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

cd02016
Location:259 → 521

TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...

pfam02779
Location:645 → 856

Transket_pyr; Transketolase, pyrimidine binding domain

pfam16078
Location:51 → 86

2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus

pfam16870
Location:863 → 1005

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
NM_001104159.3 → NP_001097629.1 oxoglutarate dehydrogenase, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097629.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JNU6

Conserved Domains (5) summary

PRK09404
Location:53 → 1104

sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

cd02016
Location:259 → 521

TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...

pfam02779
Location:645 → 856

Transket_pyr; Transketolase, pyrimidine binding domain

pfam16078
Location:51 → 86

2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus

pfam16870
Location:863 → 1102

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
NM_176342.5 → NP_788520.2 oxoglutarate dehydrogenase, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788520.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQQ0

Conserved Domains (6) summary

PRK09404
Location:53 → 1016

sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

cd02016
Location:268 → 530

TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...

pfam02779
Location:654 → 865

Transket_pyr; Transketolase, pyrimidine binding domain

pfam16078
Location:51 → 86

2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus

pfam16870
Location:872 → 1014

OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

cl06123
Location:178 → 226

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins