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    Fkbp14 FK506-binding protein 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37449, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fkbp14provided by FlyBase
    Official Full Name
    FK506-binding protein 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0010470
    Locus tag
    Dmel_CG9847
    See related
    AllianceGenome:FB:FBgn0010470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.GM07659; BcDNA:GH08925; BcDNA:GM07659; CG9847; Dmel\CG9847; FKB13; fkbp13; Fkbp13; FKBP13; FKBP14; GM07659; l(2)00734
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including imaginal disc-derived wing margin morphogenesis; muscle cell cellular homeostasis; and positive regulation of Notch signaling pathway. Located in endoplasmic reticulum and extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic anal pad; embryonic dorsal epidermis; and glomerulus. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14) and FKBP7 (FKBP prolyl isomerase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fkbp14 in Genome Data Viewer
    Location:
    57E6-57E6; 2-95 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21487167..21497929, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17374672..17385434, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A oxidase at 57D distal Neighboring gene Syndecan Neighboring gene Smad anchor for receptor activation Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit C-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural selection on sleep duration in Drosophila melanogaster. Souto-Maior C, et al. Sci Rep, 2020 Nov 26. PMID 33244154, Free PMC Article
    2. Identification of fat-cell enhancer activity in Drosophila melanogaster using P-element enhancer traps. Hoshizaki DK, et al. Genome, 1995 Jun. PMID 7557362
    3. Characterization of differentially expressed genes in purified Drosophila follicle cells: toward a general strategy for cell type-specific developmental analysis. Bryant Z, et al. Proc Natl Acad Sci U S A, 1999 May 11. PMID 10318923, Free PMC Article
    4. Targeting expression to projection neurons that innervate specific mushroom body calyx and antennal lobe glomeruli in larval Drosophila. Masuda-Nakagawa LM, et al. Gene Expr Patterns, 2010 Oct-Dec. PMID 20659588
    5. The heparan sulfate proteoglycan syndecan is an in vivo ligand for the Drosophila LAR receptor tyrosine phosphatase. Fox AN, et al. Curr Biol, 2005 Oct 11. PMID 16213816

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FKBP14 is an essential gene that regulates Presenilin protein levels and Notch signaling in Drosophila.
      Title: FKBP14 is an essential gene that regulates Presenilin protein levels and Notch signaling in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FK506-binding protein 14
    Names
    CG9847-PA
    CG9847-PC
    CG9847-PD
    CG9847-PE
    CG9847-PF
    FK506-binding protein 14 ortholog
    Fkbp13
    Fkbp14-PA
    Fkbp14-PC
    Fkbp14-PD
    Fkbp14-PE
    Fkbp14-PF
    NP_001246448.1
    NP_001286679.1
    NP_001286680.1
    NP_476973.1
    NP_726074.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21487167..21497929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166452.3 → NP_726074.2  FK506-binding protein 14, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726074.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL72, Q8MLW1, Q9V3V2
      Conserved Domains (3) summary
      cd00051
      Location:141 → 208
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:37 → 130
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:140 → 208
      EF-hand_7; EF-hand domain pair

    2. NM_057625.5 → NP_476973.1  FK506-binding protein 14, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL72, Q8MLW1, Q9V3V2
      Related
      FBpp0071620
      Conserved Domains (3) summary
      cd00051
      Location:141 → 208
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:37 → 130
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:140 → 208
      EF-hand_7; EF-hand domain pair

    3. NM_001259519.2 → NP_001246448.1  FK506-binding protein 14, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246448.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7C5, Q6NL72
      Conserved Domains (3) summary
      pfam00254
      Location:37 → 130
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:140 → 212
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:141 → 212
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. NM_001299750.1 → NP_001286679.1  FK506-binding protein 14, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286679.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL72, Q8MLW1, Q9V3V2
      Conserved Domains (3) summary
      cd00051
      Location:141 → 208
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:37 → 130
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:140 → 208
      EF-hand_7; EF-hand domain pair

    5. NM_001299751.1 → NP_001286680.1  FK506-binding protein 14, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL72, Q8MLW1, Q9V3V2
      Conserved Domains (3) summary
      cd00051
      Location:141 → 208
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00254
      Location:37 → 130
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:140 → 208
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7C5 A0A0B4K7C5
    Q3YNC0 Q3YNC0
    Q3YNC1 Q3YNC1
    Q9V3V2 Q9V3V2
    Q9XZ54 Q9XZ54

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