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    CG32579 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318096, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG32579provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052579
    Locus tag
    Dmel_CG32579
    See related
    AllianceGenome:FB:FBgn0052579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG32579; XKR; XXR
    Summary
    Enables phospholipid scramblase activity. Involved in plasma membrane phospholipid scrambling. Is active in plasma membrane. Is expressed in organism. Orthologous to several human genes including XKR6 (XK related 6) and XKR9 (XK related 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG32579 in Genome Data Viewer
    Location:
    14B12-14B13; 1-53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16323286..16325768)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16217319..16219801)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Strumpellin and WASH-interacting protein Neighboring gene Cyclophilin 1 Neighboring gene uncharacterized protein Neighboring gene Calpain C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cellular function of (a)symmetric biological membranes. Nagao K, et al. Emerg Top Life Sci, 2023 Mar 31. PMID 36562339
    2. Molecular cloning and RNA expression of a novel Drosophila calpain, Calpain C. Spadoni C, et al. Biochem Biophys Res Commun, 2003 Mar 28. PMID 12646209
    3. Apoptotic extracellular vesicle formation via local phosphatidylserine exposure drives efficient cell extrusion. Kira A, et al. Dev Cell, 2023 Jul 24. PMID 37315563
    4. Extreme deformability of insect cell membranes is governed by phospholipid scrambling. Shiomi A, et al. Cell Rep, 2021 Jun 8. PMID 34107250
    5. Effectors of alcohol-induced cell killing in Drosophila. Chen P, et al. Cell Death Differ, 2012 Oct. PMID 22539005, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process involved in development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in engulfment of apoptotic cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylserine exposure on apoptotic cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane phospholipid scrambling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32579-PA
    CG32579-PB
    CG32579-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16323286..16325768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272678.1 → NP_001259607.1  uncharacterized protein Dmel_CG32579, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHV9
      Conserved Domains (1) summary
      pfam09815
      Location:25 → 211
      XK-related; XK-related protein

    2. NM_001272677.2 → NP_001259606.1  uncharacterized protein Dmel_CG32579, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259606.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHA4, Q5GH16
      Conserved Domains (1) summary
      pfam09815
      Location:25 → 353
      XK-related; XK-related protein

    3. NM_167501.2 → NP_727957.1  uncharacterized protein Dmel_CG32579, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727957.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5GH16, Q8IR18
      Related
      FBpp0074004
      Conserved Domains (1) summary
      pfam09815
      Location:25 → 346
      XK-related; XK-related protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHA4 M9PHA4
    M9PHV9 M9PHV9
    Q8IR18 Q8IR18

    Gene LinkOut

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