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    CG5347 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32403, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5347provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030578
    Locus tag
    Dmel_CG5347
    See related
    AllianceGenome:FB:FBgn0030578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5347
    Summary
    Predicted to enable RNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in protein polyubiquitination. Predicted to be part of ribonucleoprotein complex. Is expressed in organism. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to several human genes including MKRN1 (makorin ring finger protein 1) and MKRN2 (makorin ring finger protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5347 in Genome Data Viewer
    Location:
    12F4-12F4; 1-49 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14776774..14777983)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14670807..14672016)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45522 Neighboring gene Antigen 5-related 2 Neighboring gene Antigen 5-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Makorin 1 Regulates Developmental Timing in Drosophila. Tran HT, et al. Mol Cells, 2018 Dec 31. PMID 30396233, Free PMC Article
    2. Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation. Dold A, et al. PLoS Genet, 2020 Jan. PMID 31978041, Free PMC Article
    3. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article
    4. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article
    5. A cautionary note for retrocopy identification: DNA-based duplication of intron-containing genes significantly contributes to the origination of single exon genes. Zhang YE, et al. Bioinformatics, 2011 Jul 1. PMID 21551137, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5347-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14776774..14777983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132742.1 → NP_572970.1  uncharacterized protein Dmel_CG5347 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VY20
      Related
      FBpp0073753, FBtr0073936
      Conserved Domains (3) summary
      smart00356
      Location:4 → 30
      ZnF_C3H1; zinc finger
      PHA03096
      Location:80 → 239
      PHA03096; p28-like protein; Provisional
      cd00162
      Location:159 → 213
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VY20 Q9VY20

    Gene LinkOut

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