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    Cyp6a14 Cytochrome P450 6a14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35835, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp6a14provided by FlyBase
    Official Full Name
    Cytochrome P450 6a14provided by FlyBase
    Primary source
    FLYBASE:FBgn0033302
    Locus tag
    Dmel_CG8687
    See related
    AllianceGenome:FB:FBgn0033302
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6a14; CG8687; Cyp6A14; CYP6A14; Dmel\CG8687
    Old locus tag
    Dmel_CR8687
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and embryonic/larval midgut. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp6a14 in Genome Data Viewer
    Location:
    44D3-44D3; 2-59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8564187..8567202, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4451692..4454707, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45308 Neighboring gene pseudo Neighboring gene Cytochrome P450 6a13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Imidacloprid is hydroxylated by Laodelphax striatellus CYP6AY3v2. Wang R, et al. Insect Mol Biol, 2017 Oct. PMID 28654199
    2. Transcriptome analysis of Drosophila melanogaster laboratory strains of different geographical origin after long-term laboratory maintenance. Zarubin M, et al. Ecol Evol, 2020 Jul. PMID 32760513, Free PMC Article
    3. Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila. Rech GE, et al. PLoS Genet, 2019 Feb. PMID 30753202, Free PMC Article
    4. Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s. Nirusimhan V, et al. Curr Drug Metab, 2022. PMID 35546755
    5. Comparative CYP-omic analysis between the DDT-susceptible and -resistant Drosophila melanogaster strains 91-C and 91-R. Seong KM, et al. Pest Manag Sci, 2018 Nov. PMID 29656515

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 6a14
    Names
    CG8687-PC
    CG8687-PE
    Cyp6a14-PC
    Cyp6a14-PE
    cytochrome P450
    NP_001286199.1
    • frameshift
    NP_610389.3
    • frameshift

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8564187..8567202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299270.1 → NP_001286199.1  cytochrome P450 6a14, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286199.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LEW9, Q9V4U7
      UniProtKB/TrEMBL
      Q29QZ6
      Conserved Domains (1) summary
      pfam00067
      Location:32 → 506
      p450; Cytochrome P450

    2. NM_136545.3 → NP_610389.3  cytochrome P450 6a14, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610389.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LEW9, Q9V4U7
      UniProtKB/TrEMBL
      Q29QZ6
      Conserved Domains (1) summary
      pfam00067
      Location:32 → 506
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4U7.3 Q9V4U7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials