U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ork1 Open rectifier K[+] channel 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32020, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ork1provided by FlyBase
    Official Full Name
    Open rectifier K[+] channel 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0017561
    Locus tag
    Dmel_CG1615
    See related
    AllianceGenome:FB:FBgn0017561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0161006.1; anon-WO0161006.22; anon-WO0161006.23; CG1615; d-ORK1; Dmel\CG1615; dOrk; dORK; DorK; dOrk1; dORK1; dORKC1; KCNK0; K[[2P]]; ork; Ork; ORK; ORK-1; ork1; ORK1
    Summary
    Enables potassium ion leak channel activity and protein homodimerization activity. Involved in locomotor rhythm; potassium ion transmembrane transport; and regulation of heart rate. Located in membrane. Part of potassium channel complex. Is expressed in several structures, including adult brain; adult head; adult muscle system; embryonic/larval heart; and ovary. Used to study heart conduction disease. Orthologous to several human genes including KCNK10 (potassium two pore domain channel subfamily K member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ork1 in Genome Data Viewer
    Location:
    9F7-9F8; 1-33 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10878054..10891250, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10772087..10785283, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45616 Neighboring gene long non-coding RNA:CR45617

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics. Kollewe A, et al. J Gen Physiol, 2009 Jul. PMID 19564427, Free PMC Article
    2. The involvement of potassium channel ORK1 in short-term memory and sleep in Drosophila. Zhang X, et al. Medicine (Baltimore), 2017 Jul. PMID 28682878, Free PMC Article
    3. Local and global methods of assessing thermal nociception in Drosophila larvae. Chattopadhyay A, et al. J Vis Exp, 2012 May 18. PMID 22643884, Free PMC Article
    4. ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. Goldstein SA, et al. Proc Natl Acad Sci U S A, 1996 Nov 12. PMID 8917578, Free PMC Article
    5. Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila. Sheeba V, et al. PLoS One, 2010 Jul 16. PMID 20661292, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggested that ORK1 might play an important role in the regulation of sleep time and short-term memory in Drosophila.
      Title: The involvement of potassium channel ORK1 in short-term memory and sleep in Drosophila.
    2. The level of Ork1 activity sets the cardiac rhythm by controlling the duration of the slow diastolic depolarization phase.
      Title: Control of cardiac rhythm by ORK1, a Drosophila two-pore domain potassium channel.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium ion leak channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of potassium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    open rectifier K[+] channel 1
    Names
    CG1615-PA
    CG1615-PB
    CG1615-PC
    CG1615-PD
    Ork1-PA
    Ork1-PB
    Ork1-PC
    Ork1-PD
    open rectifier K+ channel 1
    open rectifier potassium channel

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10878054..10891250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167259.3 → NP_727466.1  open rectifier K[+] channel 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727466.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIM4, Q0KHU1, Q32KC8, Q94526, Q95TX7
      UniProtKB/TrEMBL
      X2JD82
      Related
      FBpp0073261
      Conserved Domains (1) summary
      pfam07885
      Location:90 → 144
      Ion_trans_2; Ion channel

    2. NM_001298167.1 → NP_001285096.1  open rectifier K[+] channel 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285096.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIM4, Q0KHU1, Q32KC8, Q94526, Q95TX7
      UniProtKB/TrEMBL
      X2JD82
      Conserved Domains (1) summary
      pfam07885
      Location:90 → 144
      Ion_trans_2; Ion channel

    3. NM_078557.5 → NP_511112.1  open rectifier K[+] channel 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511112.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIM4, Q0KHU1, Q32KC8, Q94526, Q95TX7
      UniProtKB/TrEMBL
      X2JD82
      Related
      FBpp0073260
      Conserved Domains (1) summary
      pfam07885
      Location:90 → 144
      Ion_trans_2; Ion channel

    4. NM_001298168.1 → NP_001285097.1  open rectifier K[+] channel 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285097.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JJC8
      Conserved Domains (1) summary
      pfam07885
      Location:90 → 144
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94526.2 Q94526
    X2JD82 X2JD82
    X2JJC8 X2JJC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools