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    Noc1 Nucleolar complex protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39240, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Noc1provided by FlyBase
    Official Full Name
    Nucleolar complex protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036124
    Locus tag
    Dmel_CG7839
    See related
    AllianceGenome:FB:FBgn0036124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe2H6; CG7839; Dmel\CG7839; NOC1
    Summary
    Involved in rRNA processing. Located in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut; embryonic/larval midgut primordium; larval somatic muscle cell; and somatic trunk mesoderm derivative. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Noc1 in Genome Data Viewer
    Location:
    68A4-68A5; 3-34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11074769..11078736)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11067869..11071836)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Molybdenum cofactor synthesis 1 Neighboring gene Prefoldin 2 Neighboring gene JIL-1 kinase Neighboring gene uncharacterized protein Neighboring gene Iodotyrosine deiodinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Anthocyanins Function as Anti-Inflammatory Agents in a Drosophila Model for Adipose Tissue Macrophage Infiltration. Valenza A, et al. Biomed Res Int, 2018. PMID 29721509, Free PMC Article
    2. Reduction of nucleolar NOC1 leads to the accumulation of pre-rRNAs and induces Xrp1, affecting growth and resulting in cell competition. Destefanis F, et al. J Cell Sci, 2022 Dec 1. PMID 36314272, Free PMC Article
    3. Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages. Zhang W, et al. Genetics, 2003 Nov. PMID 14668387, Free PMC Article
    4. Identification of EMS-induced mutations in Drosophila melanogaster by whole-genome sequencing. Blumenstiel JP, et al. Genetics, 2009 May. PMID 19307605, Free PMC Article
    5. A Drosophila model targets Eiger/TNFα to alleviate obesity-related insulin resistance and macrophage infiltration. Mirzoyan Z, et al. Dis Model Mech, 2023 Nov 1. PMID 37828911, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Noc1p-Noc2p complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar complex protein 1
    Names
    CG7839-PA
    Noc1-PA
    anon-fast-evolving-2H6
    nucleolar complex protein-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11074769..11078736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140174.5 → NP_648431.3  nucleolar complex protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648431.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSS0, Q9VTE6
      Related
      FBpp0075937
      Conserved Domains (3) summary
      COG5593
      Location:211 → 955
      COG5593; Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]
      pfam03914
      Location:582 → 801
      CBF; CBF/Mak21 family
      pfam12726
      Location:499 → 638
      SEN1_N; SEN1 N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSS0 Q8MSS0
    Q9NHZ0 Q9NHZ0
    Q9VTE6 Q9VTE6
    Q9VTE6.3

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