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    Fem-1 Fem-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fem-1provided by FlyBase
    Official Full Name
    Fem-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034542
    Locus tag
    Dmel_CG9025
    See related
    AllianceGenome:FB:FBgn0034542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9025; dFEM-1; dFEM1B; Dmel\CG9025
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of ubiquitin-protein transferase activity. Predicted to be part of ubiquitin ligase complex. Is expressed in spermatozoon. Orthologous to human FEM1B (fem-1 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fem-1 in Genome Data Viewer
    Location:
    57A9-57A9; 2-91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20662474..20667306, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16549979..16554811, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Leucine-rich tendon-specific protein Neighboring gene transfer RNA:Tryptophan-CCA 1-1 Neighboring gene transfer RNA:Tryptophan-CCA 1-2 Neighboring gene uncharacterized protein Neighboring gene exuperantia Neighboring gene galla-1 Neighboring gene Gustatory receptor 57a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Accumulation of Spock and Worf, two novel non-LTR retrotransposons, on the neo-Y chromosome of Drosophila miranda. Bachtrog D. Mol Biol Evol, 2003 Feb. PMID 12598683
    2. On the genomic location of the exuperantia1 gene in Drosophila miranda: the limits of in situ hybridization experiments. Bachtrog D, et al. Genetics, 2003 Jul. PMID 12871928, Free PMC Article
    3. Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster. Sattelle DB, et al. Bioessays, 2005 Apr. PMID 15770687
    4. FEM1 proteins are ancient regulators of SLBP degradation. Dankert JF, et al. Cell Cycle, 2017 Mar 19. PMID 28118078, Free PMC Article
    5. Protein evolution and codon usage bias on the neo-sex chromosomes of Drosophila miranda. Bachtrog D. Genetics, 2003 Nov. PMID 14668377, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fem-1
    Names
    CG9025-PA
    CG9025-PB
    Fem-1-PA
    Fem-1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20662474..20667306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137664.3 → NP_611508.1  Fem-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUF6
      Related
      FBpp0085558
      Conserved Domains (4) summary
      cd00204
      Location:142 → 262
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:180 → 266
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:244 → 294
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:178 → 206
      ANK; ANK repeat [structural motif]

    2. NM_166408.2 → NP_725993.1  Fem-1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZBY0, A1ZBY1, Q8IGM5, Q8MS72
      Related
      FBpp0085559
      Conserved Domains (4) summary
      cd00204
      Location:90 → 210
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:128 → 214
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:192 → 242
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:126 → 154
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBY1.1 A1ZBY1

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