in inturned [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: inprovided by FlyBase
Official Full Name: inturnedprovided by FlyBase
Primary source: FLYBASE:FBgn0001259
Locus tag: Dmel_CG16993
See related: AllianceGenome:FB:FBgn0001259
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: B; CG16993; Dmel\CG16993; In
Summary: Involved in non-sensory hair organization. Predicted to be located in plasma membrane. Predicted to be active in cilium and cytoplasm. Is expressed in several structures, including antennal anlage; antennal primordium; central brain anlage; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy and orofaciodigital syndrome XVII. Orthologous to human INTU (inturned planar cell polarity protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20367198..20370259)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20360298..20363359)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.
Title: Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.
the Planar Polarity Effector proteins inturned, fuzzy, and fritz interact physically and can modulate the accumulation of each other in wing cells.
Title: The proteins encoded by the Drosophila Planar Polarity Effector genes inturned, fuzzy and fritz interact physically and can re-pattern the accumulation of "upstream" Planar Cell Polarity proteins.
Epistatic to frizzled in some, but not all, body regions and cell types.
Title: The function of the frizzled pathway in the Drosophila wing is dependent on inturned and fuzzy.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in establishment of imaginal disc-derived wing hair orientation	TAS Traceable Author Statement more info	PubMed
involved_in establishment of planar polarity	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-sensory hair organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed