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    unc-45 uncoordinated 45 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-45provided by FlyBase
    Official Full Name
    uncoordinated 45provided by FlyBase
    Primary source
    FLYBASE:FBgn0288846
    Locus tag
    Dmel_CG2708
    See related
    AllianceGenome:FB:FBgn0288846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2708; Dmel\CG2708; DmUnc-45; DmUNC-45; dunc-45; dUnc-45; dUNC-45; dUnc45; l(3)03692; lincRNA.721; pup; Tom34; UNC-45; Unc45; UNC45
    Summary
    Involved in several processes, including cellular response to heat; chaperone-mediated protein folding; and myosin filament assembly. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; dorsal vessel; muscle cell; and somatic muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See unc-45 in Genome Data Viewer
    Location:
    84E9-84E9; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8033301..8037403)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3859023..3862374)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ecdysone-inducible gene E3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44936 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability. Lee CF, et al. J Cell Sci, 2011 Mar 1. PMID 21285246, Free PMC Article
    2. Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase. Melkani GC, et al. Biochem Biophys Res Commun, 2010 May 28. PMID 20403336, Free PMC Article
    3. A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair. Lechuga S, et al. FASEB J, 2022 May. PMID 35344227, Free PMC Article
    4. Drosophila as a potential model to ameliorate mutant Huntington-mediated cardiac amyloidosis. Trujillo AS, et al. Rare Dis, 2014. PMID 26942103, Free PMC Article
    5. Coactosin-like protein 1 regulates integrity and repair of model intestinal epithelial barriers via actin binding dependent and independent mechanisms. Lechuga S, et al. Front Cell Dev Biol, 2024. PMID 39040043, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of Drosophila larval muscle structure and function by UNC45 knockdown.
      Title: Disruption of Drosophila larval muscle structure and function by UNC45 knockdown.
    2. UNC-45 plays a crucial role in stabilizing myosin
      Title: The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model.
    3. Data indicate that dUNC-45 is important for myosin accumulation and muscle function, and suggest that dUNC-45 acts post-translationally for proper myosin folding and maturation.
      Title: Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability.
    4. UCS proteins, such as UNC-45, influence muscle contraction and other myosin-dependent motile processes. DmUNC-45 function is afforded by its flexibility and by structural integrity of its UCS domain.
      Title: X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster.
    5. DUNC-45 prevents inter- or intra-molecular aggregates of skeletal muscle heavy meromyosin caused by elevated temperatures.
      Title: Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in myosin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of innate immune response HMP PubMed 
    involved_in somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncoordinated 45
    Names
    CG2708-PA
    CG2708-PB
    poulpe
    translocase of outer membrane 34
    unc-45-PA
    unc-45-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8033301..8037403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316496.1 → NP_001303425.1  uncoordinated 45, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960B1, Q9VHW4
      Conserved Domains (6) summary
      smart00028
      Location:50 → 83
      TPR; Tetratricopeptide repeats
      cd00020
      Location:668 → 788
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00006
      Location:16 → 41
      TPR; TPR repeat [structural motif]
      pfam11701
      Location:351 → 494
      UNC45-central; Myosin-binding striated muscle assembly central
      pfam13414
      Location:12 → 81
      TPR_11; TPR repeat
      sd00043
      Location:753 → 789
      ARM; armadillo repeat [structural motif]

    2. NM_080057.4 → NP_524796.1  uncoordinated 45, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524796.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960B1, Q9VHW4
      Related
      FBpp0081284
      Conserved Domains (6) summary
      smart00028
      Location:50 → 83
      TPR; Tetratricopeptide repeats
      cd00020
      Location:668 → 788
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00006
      Location:16 → 41
      TPR; TPR repeat [structural motif]
      pfam11701
      Location:351 → 494
      UNC45-central; Myosin-binding striated muscle assembly central
      pfam13414
      Location:12 → 81
      TPR_11; TPR repeat
      sd00043
      Location:753 → 789
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960B1 Q960B1
    Q9VHW4 Q9VHW4

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