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    Tudor-SN Tudor staphylococcal nuclease [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38045, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tudor-SNprovided by FlyBase
    Official Full Name
    Tudor staphylococcal nucleaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035121
    Locus tag
    Dmel_CG7008
    See related
    AllianceGenome:FB:FBgn0035121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7008; Dmel\CG7008; dP100; p100; SND1; Tsn; TSN; TSN-1; tudor-SN; TUDOR-SN
    Summary
    Enables nuclease activity. Involved in spermatogenesis. Located in cytoplasm and nucleus. Part of RISC complex. Is expressed in several structures, including adult brain; adult head; adult heart; adult median bundle; and gonad. Orthologous to human SND1 (staphylococcal nuclease and tudor domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tudor-SN in Genome Data Viewer
    Location:
    61B3-61B3; 3-1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (259043..264380, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (259043..264380, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Enhancer of bithorax Neighboring gene methuselah-like 14 Neighboring gene DISCO Interacting Protein 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene wee Augmin Neighboring gene mitochondrial ribosomal protein L17 Neighboring gene uncharacterized protein Neighboring gene midkine and pleiotrophin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and ligand binding of the extended Tudor domain of D. melanogaster Tudor-SN. Friberg A, et al. J Mol Biol, 2009 Apr 10. PMID 19232356
    2. Structure of an atypical Tudor domain in the Drosophila Polycomblike protein. Friberg A, et al. Protein Sci, 2010 Oct. PMID 20669242, Free PMC Article
    3. Chromatin insulator factors involved in long-range DNA interactions and their role in the folding of the Drosophila genome. Vogelmann J, et al. PLoS Genet, 2014 Aug. PMID 25165871, Free PMC Article
    4. Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila. Ku HY, et al. PLoS Genet, 2016 Jan. PMID 26808625, Free PMC Article
    5. Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes. Kim K, et al. RNA, 2007 Jan. PMID 17123955, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results reveal the biological function of TSN and its contrasting modes of interaction with Piwi in spermatogenesis, transposon silencing, and piRNA biogenesis.
      Title: Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila.
    2. the aromatic cage of the Tudor domain binds a peptide containing symmetrically dimethylated arginines (sDMA) with micromolar affinity, while the same peptide comprising nonmethylated arginines does not show significant chemical shift perturbations
      Title: Structure and ligand binding of the extended Tudor domain of D. melanogaster Tudor-SN.
    3. Tudor-SN (tudor staphylococcal nuclease)--a protein containing five staphylococcal/micrococcal nuclease domains and a tudor domain--is a component of the RISC enzyme in Caenorhabditis elegans, Drosophila and mammals
      Title: A micrococcal nuclease homologue in RNAi effector complexes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNAi effector complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tudor staphylococcal nuclease
    Names
    CG7008-PA
    CG7008-PB
    Tudor-SN-PA
    Tudor-SN-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      259043..264380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274266.1 → NP_001261195.1  tudor staphylococcal nuclease, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261195.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T0F1, Q9W0S7
      Conserved Domains (3) summary
      smart00318
      Location:538 → 672
      SNc; Staphylococcal nuclease homologues
      pfam00567
      Location:697 → 817
      TUDOR; Tudor domain
      cl00140
      Location:346 → 504
      SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.

    2. NM_138177.3 → NP_612021.1  tudor staphylococcal nuclease, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612021.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T0F1, Q9W0S7
      Related
      FBpp0072419
      Conserved Domains (3) summary
      smart00318
      Location:538 → 672
      SNc; Staphylococcal nuclease homologues
      pfam00567
      Location:697 → 817
      TUDOR; Tudor domain
      cl00140
      Location:346 → 504
      SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0S7.1 Q9W0S7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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