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    mor moira [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41942, updated on 9-Dec-2024

    Summary

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    Official Symbol
    morprovided by FlyBase
    Official Full Name
    moiraprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002783
    Locus tag
    Dmel_CG18740
    See related
    AllianceGenome:FB:FBgn0002783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bap155; BAP155; CG18740; CG4275; Dmel\CG18740; dmMOIRA; E(E2F)3B; l(3)89B1; Moi; Moira; MOIRA; Mor; MOR; MOR/BAP155; Swi3D
    Summary
    Predicted to enable histone binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; negative regulation of neuroblast proliferation; and regulation of DNA-templated transcription. Located in nucleus. Part of brahma complex. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic/larval midgut primordium; ganglia; gut section; and mesoderm. Used to study Coffin-Siris syndrome and opportunistic bacterial infectious disease. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 8 and hydrocephalus. Orthologous to human SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1) and SMARCC2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See mor in Genome Data Viewer
    Location:
    89A8-89A11; 3-58 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15968134..15972913, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11793856..11798635, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Retinoblastoma-family protein 2 Neighboring gene Helicase 89B Neighboring gene long non-coding RNA:CR44133 Neighboring gene serpent

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intraproteomic networks: new forays into predicting interaction partners. Aravind L, et al. Genome Res, 2002 Aug. PMID 12176922
    2. GBAF, a small BAF sub-complex with big implications: a systematic review. Innis SM, et al. Epigenetics Chromatin, 2020 Nov 3. PMID 33143733, Free PMC Article
    3. Characterization of the extended Myb-like DNA-binding domain of trithorax group protein Zeste. Mohrmann L, et al. J Biol Chem, 2002 Dec 6. PMID 12354778
    4. Transcription co-activator SAYP mediates the action of STAT activator. Panov VV, et al. Nucleic Acids Res, 2012 Mar. PMID 22123744, Free PMC Article
    5. The Drosophila homeotic gene moira regulates expression of engrailed and HOM genes in imaginal tissues. Brizuela BJ, et al. Mech Dev, 1997 Jul. PMID 9256357

    See all (241) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of brahma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    moira
    Names
    Bap155/Moira
    CG18740-PA
    CG18740-PB
    MOIRA
    brahma associated protein 155 kDa
    brahma-associated protein 155
    brahma-like
    mor-PA
    mor-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15968134..15972913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202301.2 → NP_001189230.1  moira, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189230.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDA0, Q7KPY3
      Conserved Domains (5) summary
      COG5259
      Location:415 → 991
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam04433
      Location:453 → 538
      SWIRM; SWIRM domain
      pfam16495
      Location:898 → 967
      SWIRM-assoc_1; SWIRM-associated region 1
      pfam16496
      Location:6 → 446
      SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
      pfam16498
      Location:738 → 801
      SWIRM-assoc_3; SWIRM-associated domain at the C-terminal

    2. NM_079649.4 → NP_524373.1  moira, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76489, O96970, Q7KPY3, Q9VF03
      Related
      FBpp0082692
      Conserved Domains (5) summary
      COG5259
      Location:417 → 742
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam04433
      Location:453 → 538
      SWIRM; SWIRM domain
      pfam16495
      Location:962 → 1031
      SWIRM-assoc_1; SWIRM-associated region 1
      pfam16496
      Location:6 → 446
      SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
      pfam16498
      Location:738 → 801
      SWIRM-assoc_3; SWIRM-associated domain at the C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JDA0 A0A0B4JDA0
    Q7KND4 Q7KND4
    Q7KPY3 Q7KPY3
    Q8MSY3 Q8MSY3
    Q9VF03 Q9VF03

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