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    Spn77Bb Serpin 77Bb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn77Bbprovided by FlyBase
    Official Full Name
    Serpin 77Bbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036969
    Locus tag
    Dmel_CG6663
    See related
    AllianceGenome:FB:FBgn0036969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6266; CG6663; Dmel\CG6663; FBgn0036969; Spn77
    Summary
    Involved in sexual reproduction. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); HMSD (histocompatibility minor serpin domain containing); and SERPINH1 (serpin family H member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Spn77Bb in Genome Data Viewer
    Location:
    77B4-77B4; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20320952..20322358)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20314052..20315458)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43875 Neighboring gene alpha Soluble NSF attachment protein Neighboring gene Serpin 77Ba Neighboring gene pseudo Neighboring gene Serpin 77Bc

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BMP signaling inhibition in Drosophila secondary cells remodels the seminal proteome and self and rival ejaculate functions. Hopkins BR, et al. Proc Natl Acad Sci U S A, 2019 Dec 3. PMID 31740617, Free PMC Article
    2. The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic. Lindsay HA, et al. Genetics, 2008 Oct. PMID 18723887, Free PMC Article
    3. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    4. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
    5. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. Xu X, et al. BMC Genomics, 2006 Oct 4. PMID 17020603, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables serine-type endopeptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin 77Bb
    Names
    CG6663-PA
    Spn77Bb-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20320952..20322358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140949.2 → NP_649206.1  serpin 77Bb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649206.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9EQZ7, Q9VWB4, Q9VWB5
      Related
      FBpp0074612
      Conserved Domains (1) summary
      cd00172
      Location:13 → 356
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWB4 Q9VWB4

    Gene LinkOut

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