Ctss cathepsin S [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctssprovided by MGI
Official Full Name: cathepsin Sprovided by MGI
Primary source: MGI:MGI:107341
See related: Ensembl:ENSMUSG00000038642 AllianceGenome:MGI:107341
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cats
Summary: This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015]
Expression: Broad expression in spleen adult (RPKM 32.7), large intestine adult (RPKM 28.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.74 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (95434097..95463716)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95526786..95556405)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Cathepsin S in Autoimmune CD25KO Mouse Improves Sjogren Disease-Like Lacrimal Gland Pathology.
Title: Inhibition of Cathepsin S in Autoimmune CD25KO Mouse Improves Sjögren Disease-Like Lacrimal Gland Pathology.
Noise exposure increase apoptosis in the hippocampus of AD mice through the upregulation of CTSS.
Title: Noise exposure increase apoptosis in the hippocampus of AD mice through the upregulation of CTSS.
Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.
Title: Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.
Cathepsin S activity controls chronic stress-induced muscle atrophy and dysfunction in mice.
Title: Cathepsin S activity controls chronic stress-induced muscle atrophy and dysfunction in mice.
Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype.
Title: Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype.
Cathepsin S deficiency improves muscle mass loss and dysfunction via the modulation of protein metabolism in mice under pathological stress conditions.
Title: Cathepsin S deficiency improves muscle mass loss and dysfunction via the modulation of protein metabolism in mice under pathological stress conditions.
Single-cell RNA sequencing of peripheral blood reveals that monocytes with high cathepsin S expression aggravate cerebral ischemia-reperfusion injury.
Title: Single-cell RNA sequencing of peripheral blood reveals that monocytes with high cathepsin S expression aggravate cerebral ischemia-reperfusion injury.
Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis.
Title: Inhibition of cathepsin S attenuates myocardial ischemia/reperfusion injury by suppressing inflammation and apoptosis.
Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells.
Title: Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells.
Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy.
Title: Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (9) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ctss (e-PCR), detects polymorphism
- UniSTS:470613

Ctss (e-PCR), detects polymorphism
- UniSTS:532126

Ctss (e-PCR), detects polymorphism
- UniSTS:532127

AJ002386 (e-PCR)
- UniSTS:163317

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	EXP Inferred from Experiment more info	PubMed
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables proteoglycan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	ISS Inferred from Sequence or Structural Similarity more info
involved_in antigen processing and presentation of peptide antigen	ISO Inferred from Sequence Orthology more info
involved_in basement membrane disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane disassembly	ISO Inferred from Sequence Orthology more info
involved_in bone resorption	ISO Inferred from Sequence Orthology more info
involved_in collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cation channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cation channel activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to acidic pH	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in early endosome lumen	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cathepsin S

Names: Cat S

NP_001254624.2

EC 3.4.22.27

NP_067256.4

EC 3.4.22.27

XP_006501038.2

EC 3.4.22.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001267695.2 → NP_001254624.2 cathepsin S isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC092203, AK028366, AK150274, BB072817

Consensus CDS

CCDS71291.1

UniProtKB/TrEMBL

F6WR04, Q3UD32

Related

ENSMUSP00000015667.4, ENSMUST00000015667.9

Conserved Domains (2) summary

smart00848
Location:37 → 96

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:124 → 339

Peptidase_C1; Papain family cysteine protease
NM_021281.3 → NP_067256.4 cathepsin S isoform 2 preproprotein

See identical proteins and their annotated locations for NP_067256.4

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.

Source sequence(s)

AK028366, BB072817

Consensus CDS

CCDS50992.1

UniProtKB/Swiss-Prot

E9QK18, O54973, O70370

UniProtKB/TrEMBL

Q8BSZ5, Q99M14

Related

ENSMUSP00000112006.3, ENSMUST00000116304.3

Conserved Domains (2) summary

smart00848
Location:36 → 95

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:123 → 338

Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

95434097..95463716

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500975.4 → XP_006501038.2 cathepsin S isoform X1

UniProtKB/TrEMBL

Q3U5K1

Conserved Domains (1) summary

pfam00112
Location:42 → 257

Peptidase_C1; Papain family cysteine protease