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    Cdc23 CDC23 cell division cycle 23 [ Mus musculus (house mouse) ]

    Gene ID: 52563, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdc23provided by MGI
    Official Full Name
    CDC23 cell division cycle 23provided by MGI
    Primary source
    MGI:MGI:1098815
    See related
    Ensembl:ENSMUSG00000024370 AllianceGenome:MGI:1098815
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030435O18; D18Ertd243e
    Summary
    Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be part of anaphase-promoting complex. Is expressed in 4-cell stage embryo; brain; cerebellum; and cerebral cortex. Used to study infertility. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 24.1), limb E14.5 (RPKM 20.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc23 in Genome Data Viewer
    Location:
    18 B1; 18 18.69 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34761401..34784802, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34628348..34651749, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene BRD8 domain containing Neighboring gene bromodomain containing 8 Neighboring gene predicted gene, 41688 Neighboring gene STARR-positive B cell enhancer ABC_E4242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:34784160-34784348 Neighboring gene STARR-positive B cell enhancer ABC_E963 Neighboring gene STARR-seq mESC enhancer starr_44210 Neighboring gene kinesin family member 20A Neighboring gene STARR-seq mESC enhancer starr_44211 Neighboring gene nuclear encoded rRNA 5S 25 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 3 Neighboring gene predicted gene, 52376 Neighboring gene cell division cycle 25C Neighboring gene ribosomal protein L29, retrotransposed

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell division cycle 23 is required for mouse oocyte meiotic maturation. Zhou Q, et al. FASEB J, 2020 Jul. PMID 32449168
    2. Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects. Fan H, et al. Hum Genet, 2023 Nov. PMID 37768355
    3. Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea. Lelli A, et al. J Neurophysiol, 2009 Jun. PMID 19339464, Free PMC Article
    4. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Ferguson CJ, et al. Mol Cell, 2022 Jan 6. PMID 34942119, Free PMC Article
    5. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects.
      Title: Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects.
    2. Cell division cycle 23 is required for mouse oocyte meiotic maturation.
      Title: Cell division cycle 23 is required for mouse oocyte meiotic maturation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein branched polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle protein 23 homolog
    Names
    APC8
    CDC23 (cell division cycle 23, yeast, homolog)
    anaphase-promoting complex subunit 8
    cyclosome subunit 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178347.4 → NP_848124.1  cell division cycle protein 23 homolog

      See identical proteins and their annotated locations for NP_848124.1

      Status: PROVISIONAL

      Source sequence(s)
      AC074335, AC145591
      Consensus CDS
      CCDS29132.1
      UniProtKB/Swiss-Prot
      Q6PD06, Q8BGZ4, Q8C0F1
      UniProtKB/TrEMBL
      A0A0R4J1W7
      Related
      ENSMUSP00000122420.2, ENSMUST00000133181.2
      Conserved Domains (5) summary
      COG0457
      Location:212 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:367 → 393
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:331 → 364
      TPR_1; Tetratricopeptide repeat
      pfam04049
      Location:28 → 154
      ANAPC8; Anaphase promoting complex subunit 8 / Cdc23
      pfam13414
      Location:367 → 430
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34761401..34784802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526084.3 → XP_006526147.1  cell division cycle protein 23 homolog isoform X1

      See identical proteins and their annotated locations for XP_006526147.1

      UniProtKB/Swiss-Prot
      Q6PD06, Q8BGZ4, Q8C0F1
      UniProtKB/TrEMBL
      G3X8W7
      Related
      ENSMUSP00000025228.6, ENSMUST00000025228.12
      Conserved Domains (3) summary
      COG2956
      Location:214 → 491
      YciM; Lipopolysaccharide biosynthesis regulator YciM, contains six TPR domains and a predicted metal-binding C-terminal domain [Cell wall/membrane/envelope biogenesis]
      sd00006
      Location:367 → 393
      TPR; TPR repeat [structural motif]
      pfam04049
      Location:45 → 148
      ANAPC8; Anaphase promoting complex subunit 8 / Cdc23
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGZ4.2 GenPept UniProtKB/Swiss-Prot:Q8BGZ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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