Rwdd1 RWD domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rwdd1provided by MGI
Official Full Name: RWD domain containing 1provided by MGI
Primary source: MGI:MGI:1913771
See related: Ensembl:ENSMUSG00000019782 AllianceGenome:MGI:1913771
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IH1; 0710001K08Rik; 2610002D06Rik; 2700069A07Rik
Summary: Involved in several processes, including androgen receptor signaling pathway; cellular response to testosterone stimulus; and positive regulation of androgen receptor activity. Located in cytoplasm. Orthologous to human RWDD1 (RWD domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 35.6), CNS E11.5 (RPKM 32.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 18.85 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (33872551..33895612, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (33996555..34019616, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data describe a new role for RWDD1 as androgen receptor (AR) coactivator; RWDD1 interacts with the androgen receptor in vitro and in vivo; AR ligand-binding dis sufficient for the interaction with RWDD1.
Title: RWDD1 interacts with the ligand binding domain of the androgen receptor and acts as a coactivator of androgen-dependent transactivation.
Rwdd1 is a novel member of the IUP family.
Title: Rwdd1, a thymus aging related molecule, is a new member of the intrinsically unstructured protein family.
Rwdd1 is a thymus involution related protein that may indirectly affect androgen receptor signaling pathway.
Title: Identification and characterization of a novel thymus aging related protein Rwdd1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to testosterone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of androgen receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RWD domain-containing protein 1

Names: DRG family-regulatory protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025614.3 → NP_079890.1 RWD domain-containing protein 1

See identical proteins and their annotated locations for NP_079890.1

Status: PROVISIONAL

Source sequence(s)

AC153962

Consensus CDS

CCDS23773.1

UniProtKB/Swiss-Prot

Q9CQK7

Related

ENSMUSP00000019917.6, ENSMUST00000019917.6

Conserved Domains (2) summary

pfam05773
Location:6 → 111

RWD; RWD domain

cl25637
Location:144 → 197

DFRP_C; DRG Family Regulatory Proteins, Tma46