Taco1 translational activator of mitochondrially encoded cytochrome c oxidase I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taco1provided by MGI
Official Full Name: translational activator of mitochondrially encoded cytochrome c oxidase Iprovided by MGI
Primary source: MGI:MGI:1917457
See related: Ensembl:ENSMUSG00000001983 AllianceGenome:MGI:1917457
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ccdc44; 2310066I18Rik
Summary: Enables mRNA binding activity; mitochondrial ribosome binding activity; and rRNA binding activity. Acts upstream of or within several processes, including mitochondrial cytochrome c oxidase assembly; motor learning; and regulation of cytochrome-c oxidase activity. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; nose; orbito-sphenoid; and pharyngo-tympanic tube. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 8. Orthologous to human TACO1 (translational activator of cytochrome c oxidase I). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 10.7), kidney adult (RPKM 7.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 68.89 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (105956885..105964861)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (106066057..106074035)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Taco1 mutant mice develop a late-onset visual impairment, motor dysfunction and cardiac hypertrophy and thus provide a useful model for future treatment trials for mitochondrial disease.
Title: Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mitochondrial ribosome binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within mitochondrial cytochrome c oxidase assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cytochrome-c oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitochondrial translation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: translational activator of cytochrome c oxidase 1

Names: coiled-coil domain-containing protein 44; translational activator of mitochondrially-encoded cytochrome c oxidase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027346.2 → NP_081622.1 translational activator of cytochrome c oxidase 1

See identical proteins and their annotated locations for NP_081622.1

Status: VALIDATED

Source sequence(s)

AK047078, AW491435

Consensus CDS

CCDS25547.1

UniProtKB/Swiss-Prot

B1AR86, Q3TI86, Q3USS8, Q8K0Z7, Q9CV09

Related

ENSMUSP00000002048.8, ENSMUST00000002048.8

Conserved Domains (1) summary

pfam01709
Location:58 → 293

Transcrip_reg; Transcriptional regulator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

105956885..105964861

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156974.1 → XP_036012867.1 translational activator of cytochrome c oxidase 1 isoform X1

Conserved Domains (1) summary

pfam01709
Location:58 → 169

Transcrip_reg; Transcriptional regulator