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    Pfdn2 prefoldin 2 [ Mus musculus (house mouse) ]

    Gene ID: 18637, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pfdn2provided by MGI
    Official Full Name
    prefoldin 2provided by MGI
    Primary source
    MGI:MGI:1276111
    See related
    Ensembl:ENSMUSG00000006412 AllianceGenome:MGI:1276111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM27
    Summary
    Predicted to enable amyloid-beta binding activity; protein folding chaperone; and unfolded protein binding activity. Acts upstream of or within protein folding. Predicted to be located in cytosol; mitochondrion; and nucleus. Predicted to be part of RPAP3/R2TP/prefoldin-like complex and prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN2 (prefoldin subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 48.2), CNS E14 (RPKM 27.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pfdn2 in Genome Data Viewer
    Location:
    1 H3; 1 79.35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171172522..171186822)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171344954..171359254)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25151 Neighboring gene predicted gene, 20045 Neighboring gene death effector domain-containing Neighboring gene STARR-positive B cell enhancer ABC_E2019 Neighboring gene nitrilase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4387 Neighboring gene kelch domain containing 9 Neighboring gene nectin cell adhesion molecule 4 Neighboring gene STARR-positive B cell enhancer ABC_E4388 Neighboring gene Rho GTPase activating protein 30 Neighboring gene STARR-positive B cell enhancer ABC_E4389

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Transgenic (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RPAP3/R2TP/prefoldin-like complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of prefoldin complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360824.1NP_001347753.1  prefoldin subunit 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC087229
      UniProtKB/TrEMBL
      F8WJ30
      Related
      ENSMUSP00000006579.5, ENSMUST00000006579.5
      Conserved Domains (1) summary
      pfam01920
      Location:2496
      Prefoldin_2; Prefoldin subunit
    2. NM_001360825.1NP_001347754.1  prefoldin subunit 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC087229
      Conserved Domains (1) summary
      pfam01920
      Location:179
      Prefoldin_2; Prefoldin subunit
    3. NM_011070.4NP_035200.2  prefoldin subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_035200.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15491.1
      UniProtKB/Swiss-Prot
      O70591, Q8R0H2
      Related
      ENSMUSP00000120106.2, ENSMUST00000135941.8
      Conserved Domains (1) summary
      pfam01920
      Location:24127
      Prefoldin_2; Prefoldin subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171172522..171186822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)