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    Rps6ka6 ribosomal protein S6 kinase polypeptide 6 [ Mus musculus (house mouse) ]

    Gene ID: 67071, updated on 3-Dec-2024

    Summary

    Official Symbol
    Rps6ka6provided by MGI
    Official Full Name
    ribosomal protein S6 kinase polypeptide 6provided by MGI
    Primary source
    MGI:MGI:1914321
    See related
    Ensembl:ENSMUSG00000025665 AllianceGenome:MGI:1914321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RSK4; S6K-alpha-6; 2610524K04Rik
    Summary
    Predicted to enable ribosomal protein S6 kinase activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of embryonic development; and negative regulation of mesoderm development. Is active in synapse. Is expressed in several structures, including axial skeleton thoracic region; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human RPS6KA6 (ribosomal protein S6 kinase A6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 15.3), CNS E11.5 (RPKM 4.6) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rps6ka6 in Genome Data Viewer
    Location:
    X E1; X 48.2 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (110297534..110447794, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (111387837..111538097, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47771 Neighboring gene STARR-seq mESC enhancer starr_47772 Neighboring gene nuclear encoded tRNA arginine 4 (anticodon CCT) Neighboring gene predicted gene 7340 Neighboring gene highly divergent homeobox

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ribosomal protein S6 kinase alpha-6
    NP_001361636.2
    NP_001385703.1
    NP_080225.2
    XP_006528463.1
    XP_006528464.1
    XP_006528465.1
    XP_006528466.1
    XP_011246008.1
    XP_011246009.1
    XP_030107348.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374707.3NP_001361636.2  ribosomal protein S6 kinase alpha-6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CR392009
      UniProtKB/Swiss-Prot
      Q7TPS0, Q8BWZ2, Q9CUR6
      UniProtKB/TrEMBL
      A2CEE7
      Related
      ENSMUSP00000094073.5, ENSMUST00000096348.10
    2. NM_001398774.1NP_001385703.1  ribosomal protein S6 kinase alpha-6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CR392009
      UniProtKB/Swiss-Prot
      Q7TPS0, Q8BWZ2, Q9CUR6
      UniProtKB/TrEMBL
      E9PUP0
      Related
      ENSMUSP00000109055.4, ENSMUST00000113428.9
    3. NM_025949.3NP_080225.2  ribosomal protein S6 kinase alpha-6 isoform 1

      See identical proteins and their annotated locations for NP_080225.2

      Status: VALIDATED

      Source sequence(s)
      AK012150, AK049349, BC054113, BY096109, CR392009
      Consensus CDS
      CCDS30356.1
      UniProtKB/Swiss-Prot
      Q7TPS0, Q8BWZ2, Q9CUR6
      UniProtKB/TrEMBL
      B1B0X3, E9QK39
      Related
      ENSMUSP00000115975.3, ENSMUST00000123951.9
      Conserved Domains (2) summary
      cd05582
      Location:193507
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:542828
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      110297534..110447794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247706.4XP_011246008.1  ribosomal protein S6 kinase alpha-6 isoform X4

      UniProtKB/Swiss-Prot
      Q7TPS0, Q8BWZ2, Q9CUR6
      Conserved Domains (2) summary
      cd05582
      Location:109423
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:458744
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
    2. XM_006528403.4XP_006528466.1  ribosomal protein S6 kinase alpha-6 isoform X3

      UniProtKB/TrEMBL
      A2CEE5
      Conserved Domains (2) summary
      cd05582
      Location:172486
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:521807
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
    3. XM_006528402.4XP_006528465.1  ribosomal protein S6 kinase alpha-6 isoform X2

      UniProtKB/Swiss-Prot
      Q7TPS0, Q8BWZ2, Q9CUR6
      Conserved Domains (2) summary
      cd05582
      Location:193507
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:542823
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
    4. XM_006528401.5XP_006528464.1  ribosomal protein S6 kinase alpha-6 isoform X1

      See identical proteins and their annotated locations for XP_006528464.1

      UniProtKB/Swiss-Prot
      Q7TPS0, Q8BWZ2, Q9CUR6
      UniProtKB/TrEMBL
      B1B0X3, E9QK39
      Conserved Domains (2) summary
      cd05582
      Location:193507
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:542828
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
    5. XM_006528400.5XP_006528463.1  ribosomal protein S6 kinase alpha-6 isoform X1

      See identical proteins and their annotated locations for XP_006528463.1

      UniProtKB/Swiss-Prot
      Q7TPS0, Q8BWZ2, Q9CUR6
      UniProtKB/TrEMBL
      B1B0X3, E9QK39
      Conserved Domains (2) summary
      cd05582
      Location:193507
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:542828
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
    6. XM_011247707.4XP_011246009.1  ribosomal protein S6 kinase alpha-6 isoform X6

      UniProtKB/Swiss-Prot
      Q7TPS0, Q8BWZ2, Q9CUR6
      Conserved Domains (2) summary
      cd05582
      Location:65379
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:414700
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
    7. XM_030251488.2XP_030107348.1  ribosomal protein S6 kinase alpha-6 isoform X5

      UniProtKB/Swiss-Prot
      Q7TPS0, Q8BWZ2, Q9CUR6
      Conserved Domains (2) summary
      cd05582
      Location:114428
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14091
      Location:463744
      STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases