U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Unc13c unc-13 homolog C [ Mus musculus (house mouse) ]

    Gene ID: 208898, updated on 9-Dec-2024

    Summary

    Official Symbol
    Unc13cprovided by MGI
    Official Full Name
    unc-13 homolog Cprovided by MGI
    Primary source
    MGI:MGI:2149021
    See related
    Ensembl:ENSMUSG00000062151 AllianceGenome:MGI:2149021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Unc13h3; Munc13-3; D9Ertd414e; 1500037O19Rik
    Summary
    Predicted to enable calmodulin binding activity and syntaxin-1 binding activity. Involved in negative regulation of synaptic plasticity and synaptic vesicle exocytosis. Acts upstream of or within chemical synaptic transmission. Is active in calyx of Held and parallel fiber to Purkinje cell synapse. Is expressed in several structures, including brain; limb interdigital region; molar; olfactory epithelium; and spinal cord mantle layer. Orthologous to human UNC13C (unc-13 homolog C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 10.0), cortex adult (RPKM 1.5) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Unc13c in Genome Data Viewer
    Location:
    9 D; 9 40.8 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (73386704..73915421, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (73479422..74008155, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 27211 Neighboring gene STARR-seq mESC enhancer starr_24633 Neighboring gene predicted gene, 53540 Neighboring gene STARR-seq mESC enhancer starr_24634 Neighboring gene STARR-seq mESC enhancer starr_24635 Neighboring gene STARR-seq mESC enhancer starr_24637 Neighboring gene STARR-seq mESC enhancer starr_24638 Neighboring gene STARR-seq mESC enhancer starr_24639 Neighboring gene STARR-seq mESC enhancer starr_24640 Neighboring gene nuclear encoded rRNA 5S 86 Neighboring gene predicted gene, 33407

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC40770, 1500037O19Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables diacylglycerol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-kinase phorbol ester receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables syntaxin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dense core granule priming IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in presynaptic dense core vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in calyx of Held IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in calyx of Held IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in calyx of Held ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in parallel fiber to Purkinje cell synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic active zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein unc-13 homolog C
    Names
    unc13 homolog 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081153.2NP_001074622.1  protein unc-13 homolog C

      See identical proteins and their annotated locations for NP_001074622.1

      Status: VALIDATED

      Source sequence(s)
      AC112267, AC124451, AC131722, AC132267, AC153359
      Consensus CDS
      CCDS40690.1
      UniProtKB/Swiss-Prot
      Q8K0T7
      Related
      ENSMUSP00000139027.2, ENSMUST00000184666.8
      Conserved Domains (5) summary
      cd04027
      Location:12161342
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:20582177
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:10941143
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:15361642
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:18842020
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      73386704..73915421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510931.5XP_006510994.1  protein unc-13 homolog C isoform X1

      See identical proteins and their annotated locations for XP_006510994.1

      Conserved Domains (5) summary
      cd04027
      Location:12161342
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:20682187
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:10941143
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:15361640
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:18942030
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    2. XM_006510934.5XP_006510997.1  protein unc-13 homolog C isoform X3

      Conserved Domains (5) summary
      cd04027
      Location:12141340
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:20562175
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:10921141
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:15341638
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:18822018
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    3. XM_006510932.5XP_006510995.1  protein unc-13 homolog C isoform X2

      Conserved Domains (5) summary
      cd04027
      Location:12141340
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:20662185
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:10921141
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:15341638
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:18922028
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    4. XM_006510928.5XP_006510991.1  protein unc-13 homolog C isoform X1

      See identical proteins and their annotated locations for XP_006510991.1

      Conserved Domains (5) summary
      cd04027
      Location:12161342
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:20682187
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:10941143
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:15361640
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:18942030
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    5. XM_006510929.5XP_006510992.1  protein unc-13 homolog C isoform X1

      See identical proteins and their annotated locations for XP_006510992.1

      Conserved Domains (5) summary
      cd04027
      Location:12161342
      C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
      cd08395
      Location:20682187
      C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
      cd00029
      Location:10941143
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam06292
      Location:15361640
      DUF1041; Domain of Unknown Function (DUF1041)
      pfam10540
      Location:18942030
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153531.1: Suppressed sequence

      Description
      NM_153531.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.