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    Trp53inp2 transformation related protein 53 inducible nuclear protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 68728, updated on 3-Dec-2024

    Summary

    Official Symbol
    Trp53inp2provided by MGI
    Official Full Name
    transformation related protein 53 inducible nuclear protein 2provided by MGI
    Primary source
    MGI:MGI:1915978
    See related
    Ensembl:ENSMUSG00000038375 AllianceGenome:MGI:1915978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tp53inp2; 1110029F20Rik
    Summary
    Enables ubiquitin binding activity. Acts upstream of or within several processes, including macroautophagy; osteoblast differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in autophagosome and nucleus. Is expressed in several structures, including 1st branchial arch; facial prominence; limb mesenchyme; nervous system; and otocyst. Orthologous to human TP53INP2 (tumor protein p53 inducible nuclear protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 127.9), heart adult (RPKM 122.6) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Trp53inp2 in Genome Data Viewer
    Location:
    2 H1; 2 77.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155223742..155231767)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155381811..155389847)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1 light chain 3 alpha Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene STARR-positive B cell enhancer ABC_E6004 Neighboring gene microRNA 695 Neighboring gene STARR-positive B cell enhancer ABC_E11173 Neighboring gene STARR-positive B cell enhancer ABC_E4511 Neighboring gene nuclear receptor coactivator 6 Neighboring gene ribosomal protein L8 pseudogene Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in autophagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tumor protein p53-inducible nuclear protein 2
    Names
    diabetes and obesity-regulated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418655.1NP_001405584.1  tumor protein p53-inducible nuclear protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL845325
      UniProtKB/Swiss-Prot
      Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
    2. NM_001418656.1NP_001405585.1  tumor protein p53-inducible nuclear protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL845325
      UniProtKB/Swiss-Prot
      Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
    3. NM_001418657.1NP_001405586.1  tumor protein p53-inducible nuclear protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL845325
      UniProtKB/Swiss-Prot
      Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
    4. NM_001418658.1NP_001405587.1  tumor protein p53-inducible nuclear protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL845325
      UniProtKB/TrEMBL
      G3UXZ2
      Related
      ENSMUSP00000133880.2, ENSMUST00000174685.8
    5. NM_001418659.1NP_001405588.1  tumor protein p53-inducible nuclear protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL845325
      UniProtKB/TrEMBL
      G3UXZ2
    6. NM_001418660.1NP_001405589.1  tumor protein p53-inducible nuclear protein 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL845325
    7. NM_001418661.1NP_001405590.1  tumor protein p53-inducible nuclear protein 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL845325
    8. NM_178111.4NP_835212.1  tumor protein p53-inducible nuclear protein 2 isoform a

      See identical proteins and their annotated locations for NP_835212.1

      Status: VALIDATED

      Source sequence(s)
      AL845325
      Consensus CDS
      CCDS16947.1
      UniProtKB/Swiss-Prot
      Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
      Related
      ENSMUSP00000037627.8, ENSMUST00000043237.14
      Conserved Domains (1) summary
      pfam14839
      Location:28212
      DOR; DOR family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155223742..155231767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252040.2XP_030107900.1  tumor protein p53-inducible nuclear protein 2 isoform X3

      Conserved Domains (1) summary
      pfam14839
      Location:72217
      DOR; DOR family
    2. XM_017319242.2XP_017174731.1  tumor protein p53-inducible nuclear protein 2 isoform X3

      Conserved Domains (1) summary
      pfam14839
      Location:72217
      DOR; DOR family