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    OCA1 putative tyrosine protein phosphatase OCA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OCA1
    Official Full Name
    putative tyrosine protein phosphatase OCA1
    Primary source
    SGD:S000005043
    Locus tag
    YNL099C
    See related
    AllianceGenome:SGD:S000005043; FungiDB:YNL099C; VEuPathDB:YNL099C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable phosphatase activity. Involved in cellular response to oxidative stress. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OCA1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (438567..439283, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Avt4p Neighboring gene Mic27p Neighboring gene Ras family GTPase RAS2 Neighboring gene Pls1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a Saccharomyces cerevisiae gene that is required for G1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide. Alic N, et al. Mol Biol Cell, 2001 Jun. PMID 11408586, Free PMC Article
    2. Lipid hydroperoxides activate the mitogen-activated protein kinase Mpk1p in Saccharomyces cerevisiae. Alic N, et al. J Biol Chem, 2003 Oct 24. PMID 12912987
    3. Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains. Wishart MJ, et al. Trends Biochem Sci, 1998 Aug. PMID 9757831
    4. A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Wang H, et al. Mol Cell Proteomics, 2009 Jun. PMID 19176519, Free PMC Article
    5. Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms. Romá-Mateo C, et al. Mol Genet Genomics, 2011 Apr. PMID 21409566

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative tyrosine protein phosphatase OCA1
    NP_014300.3
    • Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      438567..439283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182937.3 → NP_014300.3  TPA: putative tyrosine protein phosphatase OCA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014300.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZRY1, D6W180, P50946, Q45U02
      UniProtKB/TrEMBL
      B3LNV8, B5VQU3, C7GR79, C8ZGD0, G2WM05, N1NZE8
      Conserved Domains (1) summary
      cd14531
      Location:66 → 218
      PFA-DSP_Oca1; atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50946.1

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