Akap14 A kinase anchor protein 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akap14provided by MGI
Official Full Name: A kinase anchor protein 14provided by MGI
Primary source: MGI:MGI:3618288
See related: Ensembl:ENSMUSG00000036551 AllianceGenome:MGI:3618288
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The human ortholog of this gene has been characterized. It is reported to be enriched in airway cilia and to regulate ciliary beat frequency by anchoring the protein kinase A holoenzyme near substrates in the axoneme. [provided by RefSeq, May 2013]
Expression: Biased expression in whole brain E14.5 (RPKM 5.8), CNS E14 (RPKM 5.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A3.3; X 21.57 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (36414351..36432495, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (37150698..37168842, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors identify and characterize the human AKAP14, also known as AKAP28, and demonstrate that recombinant AKAP14 co-purifies with the catalytic subunit of protein kinase A and that endogenous AKAP14 localizes to airway cilia.
Title: Characterization of an A-kinase anchoring protein in human ciliary axonemes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

RH125507 (e-PCR)
- UniSTS:162325

AA987160 (e-PCR)
- UniSTS:166179

D20S1001 (e-PCR)
- UniSTS:154617

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in sperm fibrous sheath	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase anchor protein 14

Names: A kinase (PRKA) anchor protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033785.2 → NP_001028957.1 A-kinase anchor protein 14

Status: REVIEWED

Source sequence(s)

AK133120

Consensus CDS

CCDS30070.1

UniProtKB/TrEMBL

Q3V0I7

Related

ENSMUSP00000048773.6, ENSMUST00000046557.6

Conserved Domains (1) summary

pfam14469
Location:408 → 528

AKAP28; 28 kDa A-kinase anchor