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    Mrpl58 mitochondrial ribosomal protein L58 [ Mus musculus (house mouse) ]

    Gene ID: 68572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrpl58provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L58provided by MGI
    Primary source
    MGI:MGI:1915822
    See related
    Ensembl:ENSMUSG00000018858 AllianceGenome:MGI:1915822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ict1; MRP-L58; 1110001A02Rik; 1110002E03Rik
    Summary
    Predicted to enable aminoacyl-tRNA hydrolase activity and translation release factor activity, codon nonspecific. Predicted to be involved in mitochondrial translational termination and rescue of stalled ribosome. Located in mitochondrion. Is expressed in several structures, including early conceptus; eye; genitourinary system; gut; and nervous system. Orthologous to human MRPL58 (mitochondrial ribosomal protein L58). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 51.0), thymus adult (RPKM 39.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl58 in Genome Data Viewer
    Location:
    11 E2; 11 80.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115294550..115303500)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115403724..115412674)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53654 Neighboring gene cerebellar degeneration-related protein 2-like Neighboring gene predicted gene, 32013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115268427-115268649 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115269568-115269824 Neighboring gene STARR-seq mESC enhancer starr_31157 Neighboring gene nuclear encoded tRNA arginine 5 (anticodon CCT) Neighboring gene nuclear encoded tRNA arginine 3 (anticodon CCT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria. Feaga HA, et al. PLoS Genet, 2016 Mar. PMID 27029019, Free PMC Article
    2. Solution structure of the catalytic domain of the mitochondrial protein ICT1 that is essential for cell vitality. Handa Y, et al. J Mol Biol, 2010 Nov 26. PMID 20869366
    3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    4. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation release factor activity, codon nonspecific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation release factor activity, codon nonspecific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity, codon nonspecific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translational termination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL62
    Names
    39S ribosomal protein L58, mitochondrial
    immature colon carcinoma transcript 1 protein homolog
    peptidyl-tRNA hydrolase ICT1, mitochondrial
    NP_001334574.1
    NP_001348391.1
    NP_001348392.1
    NP_081005.1
    XP_030102123.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347645.1 → NP_001334574.1  large ribosomal subunit protein mL62 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AW495606, BB857370, BC079614, CX566707
      Consensus CDS
      CCDS83928.1
      UniProtKB/Swiss-Prot
      A2A6T2, A2A6T3, Q3TUL0, Q8R035, Q9CTK1, Q9D1R3
      Related
      ENSMUSP00000116746.2, ENSMUST00000153983.8

    2. NM_001361462.1 → NP_001348391.1  large ribosomal subunit protein mL62 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AW495606, BC079614, BY137982
      Consensus CDS
      CCDS88282.1
      UniProtKB/TrEMBL
      A2A6T4
      Related
      ENSMUSP00000102149.4, ENSMUST00000106539.10
      Conserved Domains (1) summary
      cl27687
      Location:75 → 182
      RF-1; RF-1 domain

    3. NM_001361463.1 → NP_001348392.1  large ribosomal subunit protein mL62 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL603828, AL627096
      Conserved Domains (1) summary
      cl27687
      Location:43 → 169
      RF-1; RF-1 domain

    4. NM_026729.2 → NP_081005.1  large ribosomal subunit protein mL62 isoform 1

      See identical proteins and their annotated locations for NP_081005.1

      Status: VALIDATED

      Source sequence(s)
      AK003192, AW456161, BY137982
      Consensus CDS
      CCDS25632.1
      UniProtKB/Swiss-Prot
      Q8R035
      Related
      ENSMUSP00000099325.5, ENSMUST00000103036.5
      Conserved Domains (1) summary
      cl23917
      Location:43 → 173
      RF-1; RF-1 domain

    RNA

    1. NR_154991.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AW456161, BQ746449, BY137982

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115294550..115303500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246263.1 → XP_030102123.1  large ribosomal subunit protein mL62 isoform X1

      Conserved Domains (1) summary
      cl29584
      Location:46 → 153
      RF-1; RF-1 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R035.1 GenPept UniProtKB/Swiss-Prot:Q8R035

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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