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Apoe apolipoprotein E [ Mus musculus (house mouse) ]

Gene ID: 11816, updated on 27-Nov-2024

Summary

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Official Symbol: Apoeprovided by MGI
Official Full Name: apolipoprotein Eprovided by MGI
Primary source: MGI:MGI:88057
See related: Ensembl:ENSMUSG00000002985 AllianceGenome:MGI:88057
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Apo-E
Summary: This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]
Expression: Biased expression in liver adult (RPKM 9050.0), liver E18 (RPKM 4149.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

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See Apoe in Genome Data Viewer

Location:: 7 A3; 7 9.94 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19430169..19434326, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19696244..19701310, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apolipoprotein E knockout, but not cholesteryl ester transfer protein (CETP)-associated high-density lipoprotein cholesterol (HDL-C) lowering, exacerbates muscle wasting in dysferlin-null mice.
Title: Apolipoprotein E knockout, but not cholesteryl ester transfer protein (CETP)-associated high-density lipoprotein cholesterol (HDL-C) lowering, exacerbates muscle wasting in dysferlin-null mice.
Effects of a high-fat diet on cognition and brain distribution of intranasal insulin in E3 and E4 male and female mice.
Title: Effects of a high-fat diet on cognition and brain distribution of intranasal insulin in E3 and E4 male and female mice.
Lack of alpha CGRP exacerbates the development of atherosclerosis in ApoE-knockout mice.
Title: Lack of alpha CGRP exacerbates the development of atherosclerosis in ApoE-knockout mice.
Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease.
Title: Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease.
Sex and APOE genotype influence respiratory function under hypoxic and hypoxic-hypercapnic conditions.
Title: Sex and APOE genotype influence respiratory function under hypoxic and hypoxic-hypercapnic conditions.
Heparanase promotes the onset and progression of atherosclerosis in apolipoprotein E gene knockout mice.
Title: Heparanase promotes the onset and progression of atherosclerosis in apolipoprotein E gene knockout mice.
Activation of Nrf2 inhibits atherosclerosis in ApoE[-/-] mice through suppressing endothelial cell inflammation and lipid peroxidation.
Title: Activation of Nrf2 inhibits atherosclerosis in ApoE(-/-) mice through suppressing endothelial cell inflammation and lipid peroxidation.
PCSK9 aggravated carotid artery stenosis in ApoE[-/-] mice by promoting the expression of tissue factors in endothelial cells via the TLR4/NF-kappaB pathway.
Title: PCSK9 aggravated carotid artery stenosis in ApoE(-/-) mice by promoting the expression of tissue factors in endothelial cells via the TLR4/NF-κB pathway.
APOE2 protects against Abeta pathology by improving neuronal mitochondrial function through ERRalpha signaling.
Title: APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling.
APOE2 Heterozygosity Reduces Hippocampal Soluble Amyloid-beta42 Levels in Non-Hyperlipidemic Mice.
Title: APOE2 Heterozygosity Reduces Hippocampal Soluble Amyloid-β42 Levels in Non-Hyperlipidemic Mice.

Submit: New GeneRIF Correction See all GeneRIFs (942)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (25) 1 citation
Spontaneous (1) 1 citation
Targeted (31) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Apoe (e-PCR), detects polymorphism
- UniSTS:141112

AI255918 (e-PCR)
- UniSTS:179533

PMC186328P2 (e-PCR)
- UniSTS:271700

Apoe (e-PCR), detects polymorphism
- UniSTS:502677

NoName (e-PCR)
- UniSTS:532416

Apoe (e-PCR), detects polymorphism
- UniSTS:532416

D7Mit57 (e-PCR), detects polymorphism
- UniSTS:131281

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISS Inferred from Sequence or Structural Similarity more info
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydroxyapatite binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipid transporter activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein particle binding	IDA Inferred from Direct Assay more info	PubMed
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal chelating activity	IEA Inferred from Electronic Annotation more info
enables metal chelating activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylcholine-sterol O-acyltransferase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables very-low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect NMDA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in acylglycerol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid precursor protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in amyloid precursor protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within artery morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within axon regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol efflux	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in chylomicron remnant clearance	ISO Inferred from Sequence Orthology more info
involved_in chylomicron remnant clearance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within circulatory system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in fatty acid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in high-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in high-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in intermediate-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in intermediate-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
involved_in lipid transport involved in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipoprotein biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipoprotein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipoprotein metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lipoprotein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in locomotory exploration behavior	IEA Inferred from Electronic Annotation more info
involved_in locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of location in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanosome organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid fibril formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of postsynaptic membrane organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of triglyceride metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in nitric oxide-cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid efflux	IEA Inferred from Electronic Annotation more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CoA-transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CoA-transferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid transport across blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipoprotein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of low-density lipoprotein particle receptor catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of low-density lipoprotein particle receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurofibrillary tangle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of presynaptic membrane organization	ISO Inferred from Sequence Orthology more info
involved_in protein import	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of Cdc42 protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of Cdc42 protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of behavioral fear response	IEA Inferred from Electronic Annotation more info
involved_in regulation of behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of plasma lipoprotein particle levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to caloric restriction	IEA Inferred from Electronic Annotation more info
involved_in response to caloric restriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reverse cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride-rich lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride-rich lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in triglyceride-rich lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in very-low-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in very-low-density lipoprotein particle remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in virion assembly	IEA Inferred from Electronic Annotation more info
involved_in virion assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
part_of chylomicron	ISO Inferred from Sequence Orthology more info
part_of chylomicron remnant	IEA Inferred from Electronic Annotation more info
part_of chylomicron remnant	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
part_of discoidal high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in extracellular vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
part_of intermediate-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of intermediate-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
part_of lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of low-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in multivesicular body, internal vesicle	IEA Inferred from Electronic Annotation more info
located_in multivesicular body, internal vesicle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info
is_active_in synaptic cleft	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: apolipoprotein E

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305819.1 → NP_001292748.1 apolipoprotein E precursor

See identical proteins and their annotated locations for NP_001292748.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.

Source sequence(s)

AI836733, AK134921, DN173921

Consensus CDS

CCDS20912.1

UniProtKB/Swiss-Prot

P08226

UniProtKB/TrEMBL

Q3TXU4, Q3UBS0, Q6GTX3

Related

ENSMUSP00000133371.2, ENSMUST00000173739.8

Conserved Domains (1) summary

pfam01442
Location:78 → 280

Apolipoprotein; Apolipoprotein A1/A4/E domain
NM_001305843.1 → NP_001292772.1 apolipoprotein E precursor

See identical proteins and their annotated locations for NP_001292772.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 encode the same protein.

Source sequence(s)

AC149282, AI836733, AK134921, BY313639, BY772289

Consensus CDS

CCDS20912.1

UniProtKB/Swiss-Prot

P08226

UniProtKB/TrEMBL

Q3TXU4, Q3UBS0, Q6GTX3

Conserved Domains (1) summary

pfam01442
Location:78 → 280

Apolipoprotein; Apolipoprotein A1/A4/E domain
NM_001305844.1 → NP_001292773.1 apolipoprotein E precursor

See identical proteins and their annotated locations for NP_001292773.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.

Source sequence(s)

AC149282, AI836733, AK134921

Consensus CDS

CCDS20912.1

UniProtKB/Swiss-Prot

P08226

UniProtKB/TrEMBL

Q3TXU4, Q3UBS0, Q6GTX3

Conserved Domains (1) summary

pfam01442
Location:78 → 280

Apolipoprotein; Apolipoprotein A1/A4/E domain
NM_009696.4 → NP_033826.2 apolipoprotein E precursor

See identical proteins and their annotated locations for NP_033826.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.

Source sequence(s)

AI836733, AK134921, BY313639, BY772289

Consensus CDS

CCDS20912.1

UniProtKB/Swiss-Prot

P08226

UniProtKB/TrEMBL

Q3TXU4, Q3UBS0, Q6GTX3

Related

ENSMUSP00000133302.2, ENSMUST00000174064.9

Conserved Domains (1) summary

pfam01442
Location:78 → 280

Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

19430169..19434326 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242015.2 → XP_030097875.1 apolipoprotein E isoform X1

UniProtKB/Swiss-Prot

P08226

UniProtKB/TrEMBL

Q3TXU4, Q3UBS0, Q6GTX3

Conserved Domains (1) summary

pfam01442
Location:78 → 280

Apolipoprotein; Apolipoprotein A1/A4/E domain