U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FMN1 riboflavin kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851822, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FMN1
    Official Full Name
    riboflavin kinase
    Primary source
    SGD:S000002644
    Locus tag
    YDR236C
    See related
    AllianceGenome:SGD:S000002644; FungiDB:YDR236C; VEuPathDB:YDR236C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables riboflavin kinase activity. Involved in FMN biosynthetic process. Located in mitochondrial inner membrane. Used to study cancer. Orthologous to human RFK (riboflavin kinase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FMN1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (935236..935892, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene homoaconitate hydratase LYS4 Neighboring gene mRNA splicing protein PRP42 Neighboring gene mitochondrial 54S ribosomal protein YmL7/YmL5 Neighboring gene coatomer subunit beta

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular characterization of FMN1, the structural gene for the monofunctional flavokinase of Saccharomyces cerevisiae. Santos MA, et al. J Biol Chem, 2000 Sep 15. PMID 10887197
    2. FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism. Chen X, et al. Nat Commun, 2020 Feb 13. PMID 32054832, Free PMC Article
    3. Characterization of a non-nudix pyrophosphatase points to interplay between flavin and NAD(H) homeostasis in Saccharomyces cerevisiae. Lynch JH, et al. PLoS One, 2018. PMID 29902190, Free PMC Article
    4. Evolution. Systematic humanization of yeast genes reveals conserved functions and genetic modularity. Kachroo AH, et al. Science, 2015 May 22. PMID 25999509, Free PMC Article
    5. Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants. Hamza A, et al. Genetics, 2015 Nov. PMID 26354769, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables riboflavin kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables riboflavin kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables riboflavin kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables riboflavin kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FMN biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in FMN biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in FMN biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in FMN biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in riboflavin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    riboflavin kinase
    NP_010522.1
    • Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      935236..935892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180544.1 → NP_010522.1  TPA: riboflavin kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSL7, Q03778
      UniProtKB/TrEMBL
      A6ZYI9, B3LG52, B5VGC3, C7GVB7, C8Z5E7, N1P8G3
      Conserved Domains (1) summary
      COG0196
      Location:1 → 207
      RibF; FAD synthase [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03778.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous