Pptc7 PTC7 protein phosphatase homolog [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pptc7provided by MGI
Official Full Name: PTC7 protein phosphatase homologprovided by MGI
Primary source: MGI:MGI:2444593
See related: Ensembl:ENSMUSG00000038582 AllianceGenome:MGI:2444593
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TA-PP2C; 9130017A15Rik
Summary: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in peptidyl-serine dephosphorylation and regulation of ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; connective tissue; genitourinary system; and gut. Orthologous to human PPTC7 (protein phosphatase targeting COQ7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 24.7), adrenal adult (RPKM 19.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.28 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (122422461..122462344)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (122284398..122324281)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.
Title: PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.
Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis.
Title: Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI848390 (e-PCR)
- UniSTS:165426

RH125598 (e-PCR)
- UniSTS:162412

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ubiquinone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of ubiquinone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase PTC7 homolog

Names: T-cell activation protein phosphatase 2C

NP_796216.2

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177242.4 → NP_796216.2 protein phosphatase PTC7 homolog

See identical proteins and their annotated locations for NP_796216.2

Status: PROVISIONAL

Source sequence(s)

AC093473, AC127266

Consensus CDS

CCDS39255.1

UniProtKB/Swiss-Prot

Q3TS53, Q6NVE9, Q8BVC7

Related

ENSMUSP00000051838.9, ENSMUST00000053426.15

Conserved Domains (1) summary

cl00120
Location:66 → 302

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...