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    HDA2 Hda2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851889, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HDA2
    Official Full Name
    Hda2p
    Primary source
    SGD:S000002703
    Locus tag
    YDR295C
    See related
    AllianceGenome:SGD:S000002703; FungiDB:YDR295C; VEuPathDB:YDR295C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PLO2
    Summary
    Enables DNA binding activity and chromatin binding activity. Contributes to histone deacetylase activity. Involved in negative regulation of transcription by RNA polymerase II and regulatory ncRNA-mediated gene silencing. Located in cytosol and nucleus. Part of HDA1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HDA2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1052623..1054647, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mRNA-binding translational repressor SSD1 Neighboring gene sphinganine-1-phosphate aldolase DPL1 Neighboring gene mitochondrial 54S ribosomal protein MHR1 Neighboring gene sphingosine hydroxylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional studies of the yeast class II Hda1 histone deacetylase complex. Lee JH, et al. J Mol Biol, 2009 Aug 28. PMID 19573535
    2. Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Lee JH, et al. Sci Adv, 2021 Jan. PMID 33523989, Free PMC Article
    3. Lysine acetylation regulates the activity of nuclear Pif1. Ononye OE, et al. J Biol Chem, 2020 Nov 13. PMID 32878983, Free PMC Article
    4. HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Wu J, et al. Proc Natl Acad Sci U S A, 2001 Apr 10. PMID 11287668, Free PMC Article
    5. Deletion of host histone acetyltransferases and deacetylases strongly affects Agrobacterium-mediated transformation of Saccharomyces cerevisiae. Soltani J, et al. FEMS Microbiol Lett, 2009 Sep. PMID 19659745

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HDA1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HDA1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of HDA1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hda2p
    NP_010581.3
    • Subunit of HDA1 histone deacetylase complex; tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; Hda2p relocalizes to cytosol in response to hypoxia; other members of the HDA1 histone deacetylase complex, which regulates aging through trehalose metabolism, are Hda1p and Hda3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1052623..1054647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180603.3 → NP_010581.3  TPA: Hda2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010581.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSS4, Q06629
      UniProtKB/TrEMBL
      G2WB33, N1P565
      Conserved Domains (2) summary
      TIGR00618
      Location:445 → 641
      sbcc; exonuclease SbcC
      pfam11496
      Location:11 → 319
      HDA2-3; Class II histone deacetylase complex subunits 2 and 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06629.1

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