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    REELD1 reeler domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 345051, updated on 4-Jan-2025

    Summary

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    Official Symbol
    REELD1provided by HGNC
    Official Full Name
    reeler domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:53638
    See related
    Ensembl:ENSG00000250673 AllianceGenome:HGNC:53638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See REELD1 in Genome Data Viewer
    Location:
    4q31.22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (146214538..146232267)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (149530515..149548244)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (147135690..147153419)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377469 Neighboring gene long intergenic non-protein coding RNA 1095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15739 Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:147143236-147144435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:147162227-147163143 Neighboring gene Sharpr-MPRA regulatory region 13307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21982 Neighboring gene solute carrier family 10 member 7 Neighboring gene uncharacterized LOC105377472 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:147250043-147251242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:147271442-147272028 Neighboring gene NANOG hESC enhancer GRCh37_chr4:147289228-147289729 Neighboring gene NANOG hESC enhancer GRCh37_chr4:147302440-147303022 Neighboring gene NANOG hESC enhancer GRCh37_chr4:147320049-147320582 Neighboring gene microRNA 7849

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Xu XR, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11752456, Free PMC Article
    2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    reelin domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354631.1 → NP_001341560.1  reelin domain-containing protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC097372
      Consensus CDS
      CCDS87268.1
      UniProtKB/Swiss-Prot
      A0A1B0GV85
      Related
      ENSP00000510273.1, ENST00000623665.2
      Conserved Domains (1) summary
      pfam02014
      Location:33 → 155
      Reeler; Reeler domain

    2. NM_001371071.1 → NP_001358000.1  reelin domain-containing protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC097372
      Consensus CDS
      CCDS87268.1
      UniProtKB/Swiss-Prot
      A0A1B0GV85
      Related
      ENSP00000490412.2, ENST00000636502.1
      Conserved Domains (1) summary
      pfam02014
      Location:33 → 155
      Reeler; Reeler domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      146214538..146232267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      149530515..149548244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1B0GV85.2 GenPept UniProtKB/Swiss-Prot:A0A1B0GV85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials