ATG13 serine/threonine protein kinase regulatory subunit ATG13 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATG13
Official Full Name: serine/threonine protein kinase regulatory subunit ATG13
Primary source: SGD:S000006389
Locus tag: YPR185W
See related: AllianceGenome:SGD:S000006389; FungiDB:YPR185W; VEuPathDB:YPR185W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: APG13
Summary: Enables armadillo repeat domain binding activity and protein kinase regulator activity. Involved in several processes, including cellular response to nitrogen starvation; macroautophagy; and protein targeting to vacuole. Located in phagophore assembly site and vacuole-isolation membrane contact site. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ATG13 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (907218..909434)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mec1 regulates PAS recruitment of Atg13 via direct binding with Atg13 during glucose starvation-induced autophagy.
Title: Mec1 regulates PAS recruitment of Atg13 via direct binding with Atg13 during glucose starvation-induced autophagy.
Cdc14 spatiotemporally dephosphorylates Atg13 to activate autophagy during meiotic divisions.
Title: Cdc14 spatiotemporally dephosphorylates Atg13 to activate autophagy during meiotic divisions.
Vacuolar protein Tag1 and Atg1-Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae.
Title: Vacuolar protein Tag1 and Atg1-Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae.
The carboxy terminus of yeast Atg13 binds phospholipid membrane via motifs that overlap with the Vac8-interacting domain.
Title: The carboxy terminus of yeast Atg13 binds phospholipid membrane via motifs that overlap with the Vac8-interacting domain.
orchestrated action of PP2A antagonizes Atg13 phosphorylation and promotes autophagy after the inactivation of TORC1
Title: Orchestrated Action of PP2A Antagonizes Atg13 Phosphorylation and Promotes Autophagy after the Inactivation of TORC1.
Atg13 provides intercomplex linkages between Atg17-Atg29-Atg31 complexes, thereby leading to supramolecular self-assembly of Atg1 complexes
Title: The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes.
These results lead to a model for autophagy initiation in which Atg1 and Atg13 are tightly associated with one another and assemble transiently into the pentameric Atg1 complex during starvation.
Title: Assembly and dynamics of the autophagy-initiating Atg1 complex.
The PAS scaffold proteins (Atg13 and Atg17) and phosphatidylinositol 3-kinase complex I were localized to a position at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS).
Title: Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae.
A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy.
Title: A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy.
An Atg13 protein-mediated self-association of the Atg1 protein kinase is important for the induction of autophagy.
Title: An Atg13 protein-mediated self-association of the Atg1 protein kinase is important for the induction of autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Cvt vesicle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nitrogen starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasm to vacuole targeting by the Cvt pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to phagophore assembly site	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein targeting to vacuole involved in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Atg1/ULK1 kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Atg1/ULK1 kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Atg1/ULK1 kinase complex	IEA Inferred from Electronic Annotation more info
part_of Atg1/ULK1 kinase complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info
located_in vacuole-isolation membrane contact site	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine protein kinase regulatory subunit ATG13

NP_015511.1

Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; contains a HORMA domain required for autophagy and for recruitment of the phosphatidylinositol 3-kinase complex subunit Atg14p to the pre-autophagosomal structure

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

907218..909434

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184282.1 → NP_015511.1 TPA: serine/threonine protein kinase regulatory subunit ATG13 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015511.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZX59, D6W4I5, Q06628

UniProtKB/TrEMBL

B3LKE4

Conserved Domains (1) summary

pfam10033
Location:15 → 264

ATG13; Autophagy-related protein 13