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    RPL12B ribosomal 60S subunit protein L12B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL12B
    Official Full Name
    ribosomal 60S subunit protein L12B
    Primary source
    SGD:S000002826
    Locus tag
    YDR418W
    See related
    AllianceGenome:SGD:S000002826; FungiDB:YDR418W; VEuPathDB:YDR418W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable large ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Involved in ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human RPL12 (ribosomal protein L12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL12B in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1301616..1302113)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative aminopeptidase Neighboring gene mRNA splicing protein SYF1 Neighboring gene DNA-directed DNA polymerase eta Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The GTPase center protein L12 is required for correct ribosomal stalk assembly but not for Saccharomyces cerevisiae viability. Briones E, et al. J Biol Chem, 1998 Nov 27. PMID 9822666
    2. Rpl12p affects the transcription of the PHO pathway high-affinity inorganic phosphate transporters and repressible phosphatases. Tu WY, et al. Yeast, 2011 Jun. PMID 21469193
    3. In vivo assembling of bacterial ribosomal protein L11 into yeast ribosomes makes the particles sensitive to the prokaryotic specific antibiotic thiostrepton. García-Marcos A, et al. Nucleic Acids Res, 2007. PMID 17940088, Free PMC Article
    4. Conformational changes induced in the Saccharomyces cerevisiae GTPase-associated rRNA by ribosomal stalk components and a translocation inhibitor. Briones C, et al. Nucleic Acids Res, 2000 Nov 15. PMID 11071938, Free PMC Article
    5. The amino terminal domain from Mrt4 protein can functionally replace the RNA binding domain of the ribosomal P0 protein. Rodríguez-Mateos M, et al. Nucleic Acids Res, 2009 Jun. PMID 19346338, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pbp1 is involved in the Ccr4- and Khd1-mediated regulation of cell growth through the association with Rpl12a and Rpl12b.
      Title: Pbp1 is involved in Ccr4- and Khd1-mediated regulation of cell growth through association with ribosomal proteins Rpl12a and Rpl12b.
    2. The authors postulate that RPL12 has an extra-ribosomal function in modulating the transcription of genes that need Pho4p activation.
      Title: Rpl12p affects the transcription of the PHO pathway high-affinity inorganic phosphate transporters and repressible phosphatases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables large ribosomal subunit rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L12B
    NP_010706.3
    • Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1301616..1302113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180726.3 → NP_010706.3  TPA: ribosomal 60S subunit protein L12B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010706.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLJ6, P05741, P0CX53, P0CX54, P17079
      UniProtKB/TrEMBL
      A6ZQP7, B3LFN8, C7GSB2, C8Z5Y0, G2WCI0, N1P771
      Conserved Domains (1) summary
      PLN03072
      Location:1 → 165
      PLN03072; 60S ribosomal protein L12; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX53.1
    P0CX54.1

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