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    putative Xaa-Pro dipeptidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850556, updated on 9-Dec-2024

    Summary

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    Official Full Name
    putative Xaa-Pro dipeptidase
    Primary source
    SGD:S000001902
    Locus tag
    YFR006W
    See related
    AllianceGenome:SGD:S000001902; FungiDB:YFR006W; VEuPathDB:YFR006W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in cytoplasm. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (156145..157752)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle lid subunit RPN11 Neighboring gene mRNA splicing protein SAD1 Neighboring gene tRNA-Phe Neighboring gene Yfh7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The COG database: a tool for genome-scale analysis of protein functions and evolution. Tatusov RL, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592175, Free PMC Article
    2. APEX2-mediated proximity labeling resolves protein networks in Saccharomyces cerevisiae cells. Singer-Krüger B, et al. FEBS J, 2020 Jan. PMID 31323700
    3. Analysis of the vacuolar luminal proteome of Saccharomyces cerevisiae. Sarry JE, et al. FEBS J, 2007 Aug. PMID 17651441
    4. Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Murakami Y, et al. Nat Genet, 1995 Jul. PMID 7670463
    5. Nuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin. Choudhry SK, et al. J Cell Biol, 2023 Sep 4. PMID 37358474, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative Xaa-Pro dipeptidase
    NP_116661.1
    • Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      156145..157752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179971.1 → NP_116661.1  TPA: putative Xaa-Pro dipeptidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116661.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTN6, P43590, Q66RB5
      UniProtKB/TrEMBL
      B5VI32, C7GYB2, C8Z7T9, G2WDE5
      Conserved Domains (2) summary
      smart01011
      Location:72 → 192
      AMP_N; Aminopeptidase P, N-terminal domain
      cd01087
      Location:237 → 508
      Prolidase; E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43590.1

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