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    Ak3 adenylate kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 56248, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ak3provided by MGI
    Official Full Name
    adenylate kinase 3provided by MGI
    Primary source
    MGI:MGI:1860835
    See related
    Ensembl:ENSMUSG00000024782 AllianceGenome:MGI:1860835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AK-3; Ak3l; Ak3l1; Akl3l
    Summary
    Predicted to enable adenylate kinase activity; identical protein binding activity; and nucleoside triphosphate adenylate kinase activity. Predicted to be involved in nucleotide metabolic process. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AK3 (adenylate kinase 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 99.4), liver adult (RPKM 67.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ak3 in Genome Data Viewer
    Location:
    19 C1; 19 23.61 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (28968715..29026122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (28995053..29048080, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA hydroxylase pseudogene Neighboring gene tektin 5 like Neighboring gene cell division cycle 37-like 1 Neighboring gene STARR-seq mESC enhancer starr_45875 Neighboring gene ribosomal protein L26 pseudogene Neighboring gene RIKEN cDNA 1700018L02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1523 Neighboring gene STARR-seq mESC enhancer starr_45878 Neighboring gene predicted gene 9895 Neighboring gene STARR-positive B cell enhancer ABC_E3249 Neighboring gene RNA terminal phosphate cyclase-like 1 Neighboring gene microRNA 101b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables GTP binding  
    enables adenylate kinase activity  
    enables adenylate kinase activity  
    enables adenylate kinase activity  
    enables identical protein binding  
    enables nucleoside triphosphate adenylate kinase activity  
    enables nucleoside triphosphate adenylate kinase activity  
    enables nucleoside triphosphate adenylate kinase activity  
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process  
    involved_in ADP biosynthetic process  
    involved_in AMP metabolic process  
    involved_in AMP metabolic process  
    involved_in AMP metabolic process  
    involved_in AMP phosphorylation  
    involved_in GTP metabolic process  
    involved_in GTP metabolic process  
    involved_in ITP metabolic process  
    involved_in ITP metabolic process  
    involved_in UTP metabolic process  
    involved_in UTP metabolic process  
    involved_in dATP metabolic process  
    involved_in nucleoside monophosphate phosphorylation  
    involved_in nucleoside triphosphate biosynthetic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in mitochondrial matrix  
    located_in mitochondrial matrix PubMed 
    located_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion  

    General protein information

    Preferred Names
    GTP:AMP phosphotransferase AK3, mitochondrial
    Names
    adenylate kinase 3 alpha-like 1
    NP_001352000.1
    NP_067274.1
    XP_006527285.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365071.1NP_001352000.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113961
      UniProtKB/TrEMBL
      Q9D8W6
      Conserved Domains (1) summary
      pfam00406
      Location:12189
      ADK; Adenylate kinase
    2. NM_021299.2NP_067274.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_067274.1

      Status: VALIDATED

      Source sequence(s)
      AK147060, AW457236
      Consensus CDS
      CCDS29730.1
      UniProtKB/Swiss-Prot
      Q3UDN7, Q8BGX5, Q9D7Z1, Q9DB57, Q9DBM5, Q9WTP7
      UniProtKB/TrEMBL
      Q9D8W6
      Related
      ENSMUSP00000025696.5, ENSMUST00000025696.5
      Conserved Domains (1) summary
      pfam00406
      Location:12190
      ADK; Adenylate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      28968715..29026122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527222.5XP_006527285.1  GTP:AMP phosphotransferase AK3, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam00406
      Location:12189
      ADK; Adenylate kinase
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