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    Pimreg PICALM interacting mitotic regulator [ Mus musculus (house mouse) ]

    Gene ID: 109212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pimregprovided by MGI
    Official Full Name
    PICALM interacting mitotic regulatorprovided by MGI
    Primary source
    MGI:MGI:1924434
    See related
    Ensembl:ENSMUSG00000020808 AllianceGenome:MGI:1924434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CATS; Fam64a; 2610008F03Rik; 6720460F02Rik
    Summary
    Predicted to be involved in cell division. Predicted to be located in nucleolus and nucleoplasm. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; integumental system; and limb. Orthologous to human PIMREG (PICALM interacting mitotic regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 26.3), limb E14.5 (RPKM 16.9) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pimreg in Genome Data Viewer
    Location:
    11 B4; 11 43.81 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (71932867..71938197)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72042428..72047372)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:71809517-71809670 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:71809714-71809823 Neighboring gene predicted gene, 23226 Neighboring gene STARR-positive B cell enhancer ABC_E9825 Neighboring gene STARR-positive B cell enhancer ABC_E8421 Neighboring gene aryl hydrocarbon receptor-interacting protein-like 1 Neighboring gene PITPNM family member 3 Neighboring gene predicted gene, 46286 Neighboring gene STARR-seq mESC enhancer starr_29899 Neighboring gene RIKEN cDNA 4933427D14 gene Neighboring gene predicted gene, 57849

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice. Hashimoto K, et al. Sci Rep, 2017 Jun 30. PMID 28667270, Free PMC Article
    2. FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis. Xu ZS, et al. Proc Natl Acad Sci U S A, 2019 May 21. PMID 31061131, Free PMC Article
    3. The CALM and CALM/AF10 interactor CATS is a marker for proliferation. Archangelo LF, et al. Mol Oncol, 2008 Dec. PMID 19383357, Free PMC Article
    4. Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics. Hashimoto K, et al. Sci Rep, 2024 Jun 14. PMID 38877142, Free PMC Article
    5. Individual retinal progenitor cells display extensive heterogeneity of gene expression. Trimarchi JM, et al. PLoS One, 2008 Feb 13. PMID 18270576, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein PIMREG
    Names
    CALM-interactor expressed in thymus and spleen homolog
    family with sequence similarity 64, member A
    protein FAM64A
    regulator of chromosome segregation protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418158.1 → NP_001405087.1  protein PIMREG

      Status: VALIDATED

      Source sequence(s)
      BX119911
      UniProtKB/Swiss-Prot
      Q8BFY7, Q8K2Z7
      UniProtKB/TrEMBL
      Q8VDW8

    2. NM_001418159.1 → NP_001405088.1  protein PIMREG

      Status: VALIDATED

      Source sequence(s)
      BX119911
      UniProtKB/Swiss-Prot
      Q8BFY7, Q8K2Z7
      UniProtKB/TrEMBL
      Q8VDW8

    3. NM_144526.4 → NP_653109.2  protein PIMREG

      See identical proteins and their annotated locations for NP_653109.2

      Status: VALIDATED

      Source sequence(s)
      BX119911
      Consensus CDS
      CCDS48840.1
      UniProtKB/Swiss-Prot
      Q8BFY7, Q8K2Z7
      UniProtKB/TrEMBL
      Q8VDW8
      Related
      ENSMUSP00000021164.4, ENSMUST00000021164.4
      Conserved Domains (1) summary
      pfam07326
      Location:1 → 221
      DUF1466; Protein of unknown function (DUF1466)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      71932867..71938197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFY7.1 GenPept UniProtKB/Swiss-Prot:Q8BFY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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