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    ENA2 Na(+)-exporting P-type ATPase ENA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ENA2
    Official Full Name
    Na(+)-exporting P-type ATPase ENA2
    Primary source
    SGD:S000002446
    Locus tag
    YDR039C
    See related
    AllianceGenome:SGD:S000002446; FungiDB:YDR039C; VEuPathDB:YDR039C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables P-type potassium transmembrane transporter activity and P-type sodium transporter activity. Involved in potassium ion transport; sodium ion transport; and transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ENA2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (531307..534582, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene lysine--tRNA ligase KRS1 Neighboring gene putative Na(+)-exporting P-type ATPase ENA5 Neighboring gene Na(+)/Li(+)-exporting P-type ATPase ENA1 Neighboring gene mitochondrial 37S ribosomal protein RSM10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide overexpression screen for sodium acetate resistance in Saccharomyces cerevisiae. Peña PV, et al. J Biotechnol, 2013 Mar 10. PMID 23262128
    2. A novel P-type ATPase from yeast involved in sodium transport. Haro R, et al. FEBS Lett, 1991 Oct 21. PMID 1657642
    3. Differential expression of two genes encoding isoforms of the ATPase involved in sodium efflux in Saccharomyces cerevisiae. Garciadeblas B, et al. Mol Gen Genet, 1993 Jan. PMID 8437581
    4. In yeast, upc2-1 confers a decrease in tolerance to LiCl and NaCl, which can be suppressed by the P-type ATPase encoded by ENA2. Leak FW Jr, et al. DNA Cell Biol, 1999 Feb. PMID 10073572
    5. Role of the glutamic and aspartic residues in Na+-ATPase function in the ZrENA1 gene of Zygosaccharomyces rouxii. Watanabe Y, et al. FEMS Microbiol Lett, 2002 Mar 19. PMID 12007651

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type sodium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables P-type potassium transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type potassium transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables P-type sodium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type sodium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type sodium transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inorganic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Na(+)-exporting P-type ATPase ENA2
    NP_010324.3
    • P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      531307..534582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180347.3 → NP_010324.3  TPA: Na(+)-exporting P-type ATPase ENA2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010324.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS27, Q01896
      UniProtKB/TrEMBL
      C8Z4W0
      Conserved Domains (1) summary
      TIGR01523
      Location:11 → 1055
      ATPase-IID_K-Na; potassium and/or sodium efflux P-type ATPase, fungal-type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01896.1

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