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    SMD1 mRNA splicing protein SMD1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852964, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SMD1
    Official Full Name
    mRNA splicing protein SMD1
    Primary source
    SGD:S000003306
    Locus tag
    YGR074W
    See related
    AllianceGenome:SGD:S000003306; FungiDB:YGR074W; VEuPathDB:YGR074W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SPP92
    Summary
    Enables mRNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nucleus. Part of U2-type spliceosomal complex and spliceosomal snRNP complex. Human ortholog(s) of this gene implicated in connective tissue disease; nephritis; proteinuria; and systemic lupus erythematosus. Orthologous to human SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SMD1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (635712..636152)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Env11p Neighboring gene Upf3p Neighboring gene U4/U6-U5 snRNP complex subunit PRP38 Neighboring gene mitochondrial 54S ribosomal protein YmL25 Neighboring gene Pex8p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human snRNP polypeptide D1 promotes pre-mRNA splicing in yeast and defines nonessential yeast Smd1p sequences. Rymond BC, et al. Nucleic Acids Res, 1993 Jul 25. PMID 8346029, Free PMC Article
    2. Convergent transcripts of the yeast PRP38-SMD1 locus encode two essential splicing factors, including the D1 core polypeptide of small nuclear ribonucleoprotein particles. Rymond BC. Proc Natl Acad Sci U S A, 1993 Feb 1. PMID 8430095, Free PMC Article
    3. U snRNP assembly in yeast involves the La protein. Xue D, et al. EMBO J, 2000 Apr 3. PMID 10747032, Free PMC Article
    4. A biochemical function for the Sm complex. Zhang D, et al. Mol Cell, 2001 Feb. PMID 11239461
    5. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Seto AG, et al. Nature, 1999 Sep 9. PMID 10490028

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SMN-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of commitment complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of commitment complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mRNA splicing protein SMD1
    NP_011588.3
    • Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      635712..636152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181203.3 → NP_011588.3  TPA: mRNA splicing protein SMD1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011588.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUK6, Q02260
      UniProtKB/TrEMBL
      A6ZV56, B3LIF2, C7GXQ3, C8Z8W8, G2WEF8
      Conserved Domains (1) summary
      cl00259
      Location:2 → 111
      Sm_like; Sm and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02260.1

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