RPS5 ribosomal 40S subunit protein S5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPS5
Official Full Name: ribosomal 40S subunit protein S5
Primary source: SGD:S000003884
Locus tag: YJR123W
See related: AllianceGenome:SGD:S000003884; FungiDB:YJR123W; VEuPathDB:YJR123W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: A structural constituent of ribosome. Involved in maturation of SSU-rRNA and ribosomal subunit export from nucleus. Part of cytosolic small ribosomal subunit. Orthologous to human RPS5 (ribosomal protein S5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPS5 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (651901..652578)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rps5 serine-223 phosphorylation is required for ribosomal small subunit maturation.
Title: Ribosomal protein uS7/Rps5 serine-223 in protein kinase-mediated phosphorylation and ribosomal small subunit maturation.
Thus, remodeling of the uS7/eIF2alpha interface appears to stabilize first the open, and then the closed state of the eukaryotic pre-initiation complex to promote accurate AUG selection in vivo.
Title: Interface between 40S exit channel protein uS7/Rps5 and eIF2α modulates start codon recognition in vivo.
The authors conclude that the Rps5 beta-hairpin is as crucial as soluble initiation factors for efficient and accurate start codon recognition.
Title: The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo.
the small ribosomal subunit (SSU) head component rpS5 and platform components are crucial components of a highly defined spatial arrangement in the head-platform interface of nascent SSUs, required for efficient processing of the predicted SSU rRNA 3' end
Title: A local role for the small ribosomal subunit primary binder rpS5 in final 18S rRNA processing in yeast.
Identification of the cis-elements required to support normal levels of transcription and accurate initiation from sites within the TATA-less and TFIID-dependent RPS5 core promoter.
Title: Highly redundant function of multiple AT-rich sequences as core promoter elements in the TATA-less RPS5 promoter of Saccharomyces cerevisiae.
Analysis of the mutant yeast strains suggests that the N-terminal part of the rpS5 may impact the ability of 40S subunits to function properly in translation and affect the efficiency of initiation.
Title: Yeast strains with N-terminally truncated ribosomal protein S5: implications for the evolution, structure and function of the Rps5/Rps7 proteins.
Negatively charged N-terminal extension of yeast rpS5 might affect the ribosomal recruitment of specific mRNAs.
Title: Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5.
Gln3-mediated transcription activated by nitrogen signal transduction is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae
Title: Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translational fidelity	ISA Inferred from Sequence Alignment more info	PubMed
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 90S preribosome	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
is_active_in ribosome	IBA Inferred from Biological aspect of Ancestor more info
located_in ribosome	IEA Inferred from Electronic Annotation more info
part_of small ribosomal subunit	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribosomal 40S subunit protein S5

NP_012657.1

Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

651901..652578

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181781.1 → NP_012657.1 TPA: ribosomal 40S subunit protein S5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012657.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWU2, P26783

UniProtKB/TrEMBL

A0A1L4AA68, A6ZQ79, B3LQK7, B5VLR5, C7GM89, C8ZBS1, G2WHC6, N1P0A2

Conserved Domains (1) summary

cd14867
Location:41 → 225

uS7_Eukaryote; Eukaryota homolog of Ribosomal Protein S7