Klra4 killer cell lectin-like receptor, subfamily A, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klra4provided by MGI
Official Full Name: killer cell lectin-like receptor, subfamily A, member 4provided by MGI
Primary source: MGI:MGI:101904
See related: Ensembl:ENSMUSG00000079852 AllianceGenome:MGI:101904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Chok; Ly49d; Klra32; Klra33; Ly-49d; ly49r<129>
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in regulation of signal transduction. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (130020693..130044242, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (130043730..130067301, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that after mouse cytomegalovirus infection, Ly49D augmented IFN-gamma production by virus-specific Ly49H(+) NK cells and preferentially promoted the generation of memory Ly49H(+) NK cells
Title: Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection.
these data demonstrate that DAP10 does associate with Ly49H and Ly49D in primary NK cells.
Title: DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.
Ly49D stimulation triggers cellular activation of CD4 and CD8 populations; Ly49D recognizes the classical hamster class I molecule Hm1-C4 on CHO cells, as demonstrated by the killing of Hm1-C4-transfected thymoma cells by Ly49D cytotoxic T cells.
Title: Ly49D engagement on T lymphocytes induces TCR-independent activation and CD8 effector functions that control tumor growth.
The MHC class I receptor Ly49D expressed on immature B cells recognizes MHC class I on peripheral tissues, inducing secretion of low levels of IFN-gamma and thereby down-regulating immature B cell homing to the lymph nodes or to sites of inflammation.
Title: Ly49D receptor expressed on immature B cells regulates their IFN-gamma secretion, actin polymerization, and homing.
Coexpression of a Ly49A transgene partially rescued NKT cell development in Ly49D/H2-Dd transgenics.
Title: Ligand-dependent inhibition of CD1d-restricted NKT cell development in mice transgenic for the activating receptor Ly49D.
Glycosylation of Ly-49D at amino acid residues NTT221-23 reduces receptor binding to H-2Dd tetramers and may represent a mechanism by which natural killer cells regulate affinity for host class I ligands.
Title: Receptor glycosylation regulates Ly-49 binding to MHC class I.
Activating Ly49D NK cell receptors are provided a mechanism for release from inhibitory receptor blockade that enables them to become important initiators of microbial, antiviral, and antitumor immunity.
Title: Expression of IFN-gamma upon triggering of activating Ly49D NK receptors in vitro and in vivo: costimulation with IL-12 or IL-18 overrides inhibitory receptors.
The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment.
Title: A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.
The Ly49D activation receptor on mouse NK cells specifically recognizes the Chinese hamster histocompatibility class I molecule associated with Chinese hamster beta 2-microglobulin (beta 2m) and is not tolerized in murine beta 2m deficiency.
Title: A ligand for the murine NK activation receptor Ly-49D: activation of tolerized NK cells from beta 2-microglobulin-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Not Applicable (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484912

NoName (e-PCR)
- UniSTS:494139

Klra4 (e-PCR), detects polymorphism
- UniSTS:143712

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: killer cell lectin-like receptor 4

Names: T-cell surface glycoprotein Ly-49D; killer cell lectin-like receptor subfamily A member 32; killer cell lectin-like receptor subfamily A member 33; lymphocyte antigen 49d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252577.2 → NP_001239506.1 killer cell lectin-like receptor 4 isoform 2

See identical proteins and their annotated locations for NP_001239506.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a longer protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC090127, AC090563

Consensus CDS

CCDS57457.1

UniProtKB/Swiss-Prot

O78026, Q60651, Q9EPA5

UniProtKB/TrEMBL

Q2TJJ5, Q542S4

Related

ENSMUSP00000114004.2, ENSMUST00000119096.2

Conserved Domains (2) summary

cd03593
Location:143 → 256

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 154

Ly49; Ly49-like protein, N-terminal region
NM_001411846.1 → NP_001398775.1 killer cell lectin-like receptor 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC090127, AC090563

UniProtKB/Swiss-Prot

O78026, Q60651, Q9EPA5

UniProtKB/TrEMBL

Q542S4
NM_010649.4 → NP_034779.1 killer cell lectin-like receptor 4 isoform 1

See identical proteins and their annotated locations for NP_034779.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the shorter isoform (1).

Source sequence(s)

AC090127, AC090563

UniProtKB/TrEMBL

Q2TJJ5

Conserved Domains (2) summary

cd03593
Location:140 → 253

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:38 → 151

Ly49; Ly49-like protein, N-terminal region