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    Itgax integrin alpha X [ Mus musculus (house mouse) ]

    Gene ID: 16411, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Itgaxprovided by MGI
    Official Full Name
    integrin alpha Xprovided by MGI
    Primary source
    MGI:MGI:96609
    See related
    Ensembl:ENSMUSG00000030789 AllianceGenome:MGI:96609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cr4; N418; Cd11c
    Summary
    Predicted to enable integrin binding activity and receptor tyrosine kinase binding activity. Involved in positive regulation of gene expression and positive regulation of myelination. Acts upstream of or within defense response to virus. Located in external side of plasma membrane. Is expressed in heart and hemolymphoid system. Orthologous to human ITGAX (integrin subunit alpha X). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 12.4), lung adult (RPKM 9.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Itgax in Genome Data Viewer
    Location:
    7 F3; 7 69.98 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127728697..127749829)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (128129526..128150657)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene integrin alpha M Neighboring gene STARR-seq mESC enhancer starr_20200 Neighboring gene STARR-positive B cell enhancer ABC_E8211 Neighboring gene predicted gene 45700 Neighboring gene mitochondrial carrier triple repeat 1 pseudogene Neighboring gene integrin, alpha D Neighboring gene predicted gene, 39091

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transfer of CD11c+ lamina propria mononuclear phagocytes from post-infectious irritable bowel syndrome causes mucosal barrier dysfunction and visceral hypersensitivity in recipient mice. Ren YJ, et al. Int J Mol Med, 2017 Jun. PMID 28440501
    2. CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Packard RR, et al. Circ Res, 2008 Oct 24. PMID 18832748, Free PMC Article
    3. Targeted delivery of tumor antigens to activated dendritic cells via CD11c molecules induces potent antitumor immunity in mice. Wei H, et al. Clin Cancer Res, 2009 Jul 15. PMID 19584156
    4. Alveolar macrophages transport pathogens to lung draining lymph nodes. Kirby AC, et al. J Immunol, 2009 Aug 1. PMID 19620319, Free PMC Article
    5. CD11c(+) Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. Sandor AM, et al. Front Immunol, 2019. PMID 30766536, Free PMC Article

    See all (187) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Downregulation of ITGAX Exacerbates Amyloid-beta Plaque Deposition in Alzheimer's Disease by Increasing Polarization of M1 Microglia.
      Title: The Downregulation of ITGAX Exacerbates Amyloid-β Plaque Deposition in Alzheimer's Disease by Increasing Polarization of M1 Microglia.
    2. Integrin CD11c regulates B cell homeostasis.
      Title: Integrin CD11c regulates B cell homeostasis.
    3. Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults.
      Title: Associations of cortical SPP1 and ITGAX with cognition and common neuropathologies in older adults.
    4. CD11c is not required by microglia to convey neuroprotection after prion infection.
      Title: CD11c is not required by microglia to convey neuroprotection after prion infection.
    5. CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
      Title: CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
    6. CD11c regulates neutrophil maturation.
      Title: CD11c regulates neutrophil maturation.
    7. PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-alpha Signaling Pathway.
      Title: PAX5/ITGAX Contributed to the Progression of Atherosclerosis by Regulation of B Differentiation via TNF-α Signaling Pathway.
    8. CD11c regulates late-stage T cell development in the thymus.
      Title: CD11c regulates late-stage T cell development in the thymus.
    9. Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils.
      Title: Modulation of surface CD11c expression tracks plasticity in murine intestinal tissue eosinophils.
    10. Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain.
      Title: Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain.
    Submit: New GeneRIF Correction See all GeneRIFs (99)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    NOT acts_upstream_of_or_within activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial tube morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myelination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrin alphaX-beta2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    integrin alpha-X
    Names
    CD11 antigen-like family member C
    CD11C (p150) alpha polypeptide
    complement receptor 4
    integrin aX
    leukocyte adhesion glycoprotein p150,95 alpha chain
    leukocyte adhesion receptor p150,95

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363984.1 → NP_001350913.1  integrin alpha-X isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124566
      UniProtKB/TrEMBL
      Q6PG66
      Conserved Domains (1) summary
      cl00057
      Location:151 → 291
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. NM_001363985.1 → NP_001350914.1  integrin alpha-X isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124566
      Consensus CDS
      CCDS90336.1
      UniProtKB/TrEMBL
      A0A0U1RNJ3, Q8C270
      Related
      ENSMUSP00000145587.2, ENSMUST00000205460.2
      Conserved Domains (1) summary
      cl00057
      Location:151 → 238
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. NM_021334.3 → NP_067309.1  integrin alpha-X isoform 1 precursor

      See identical proteins and their annotated locations for NP_067309.1

      Status: VALIDATED

      Source sequence(s)
      AC124566
      Consensus CDS
      CCDS40150.1
      UniProtKB/Swiss-Prot
      Q9QXH4
      UniProtKB/TrEMBL
      Q3TD13, Q3U1P9
      Related
      ENSMUSP00000033053.7, ENSMUST00000033053.8
      Conserved Domains (4) summary
      smart00191
      Location:518 → 573
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:151 → 326
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam00357
      Location:1138 → 1152
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:616 → 987
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127728697..127749829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_378219.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXH4.1 GenPept UniProtKB/Swiss-Prot:Q9QXH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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